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P300 topography of amplitude/latency correlations

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Summary

The correlational association from 19 electrode sites between peak amplitude and latency for the P3(00) event-related brain potential (ERP) for n=80 homogeneous subjects was assessed using a simple auditory discrimination task. The correlation strength varied systematically across scalp topography in different ways for the various ERP components. For the target stimuli, P3 amplitude and latency were negatively correlated and most tightly coupled over the frontal-central and right medial/lateral recording sites. In contrast, the N1 produced negative correlations that were strongest over the left and right central/lateral locations; P2 demonstrated a positive correlation that was strongest frontally and centrally; N2 demonstrated a positive correlations that was strongest over the central and parietal sites. ERPs from the standard stimuli produced generally similar patterns for the P3 and P2 components, with only weak or no reliable effects observed for the N1 and N2 potentials. Taken together, the findings suggest that analysis of amplitude/latency correlational relationships can provide information about ERP component generation. Theoretical implications are discussed.

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Authors and Affiliations

  1. Department of Neuropharmacology TPC-10, The Scripps Research Institute, 10550 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    John Polich

  2. Department of Psychology, Western Oregon University, Monmouth, OR, USA

    Joel E. Alexander

  3. Department of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA

    Lance O. Bauer

  4. Department of Psychiatry, University of Iowa, Iowa City, IA, USA

    Samuel Kuperman

  5. Department of Psychiatry, Institute of Psychiatric Research, Indianapolis, IN, USA

    Sandra Morzorati & Sean J. O'Connor

  6. Department of Psychiatry, Washington University, St. Louis, MO, USA

    J. Rohrbaugh

  7. Deparrment of Psychiatry, SUNY Health Sciences Center, Brooklyn, NY, USA

    Bernice Porjesz & Henri Begleiter

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  1. John Polich
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  2. Joel E. Alexander
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  3. Lance O. Bauer
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  4. Samuel Kuperman
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  5. Sandra Morzorati
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  6. Sean J. O'Connor
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  7. Bernice Porjesz
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  8. J. Rohrbaugh
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  9. Henri Begleiter
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Correspondence to John Polich.

Additional information

Collaborative studies on the Genetics of Alcoholism (H. Begleiter, SUNY HSCB, Principal Investigator, T. Reich, Washington University, Co-Principal Investigator) includes six different centers where data collection takes place. The six sites and Principal Investigator and Co-Investigators are: Indiana University (J. Nurnberger, Jr., P.M. Conneally); University of Iowa (R. Crow, S. Kuperman); University of California, San Diego and The Scripps Research Institute (M. Schuckit, F.E. Bloom); University of Connecticut (V. Hesselbrock); State University of New York, Health Science Center at Brooklyn (H. Begleiter, B. Porjesz); Washington University in St. Louis (T. Reich, C.R. Cloninger). This national collaborative study is supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAAA) by U.S.P.H.S. grant U10AA08402-07, This paper is publication number NP10292 from The Scripps Research Institute.

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Polich, J., Alexander, J.E., Bauer, L.O. et al. P300 topography of amplitude/latency correlations. Brain Topogr 9, 275–282 (1997). https://doi.org/10.1007/BF01464482

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