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Considerazioni sull'azione dell'insulina sul metabolismo dei carboidrati nel fegato

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Riassunto

Viene presentata una sintetica rassegna delle ricerche con le quali si è tentato di dimostrare un effetto diretto dell'insulina sul ricambio dei carboidrati nel fegato, nel senso di un'accelerazione della glicogenogenesi epatica, o di un blocco della glicogenolisi epatica, o di un'accelerazione della glicolisi epatica.

Si conclude che effetti insulinici diretti sul metabolismo epatico dei carboidrati, benchè verosimili, non possono considerarsi definitivamente dimostrati.

Si accenna anche al problema del meccanismo dell'eventuale azione insulinica sull'epatocita.

Resume

L'A. présente une révue sinthétique des recherches qui ont eu pour but de demonstrer un effect direct de l'insuline sur le métabolisme glycidique dans le foie, du point de vue d'une accélération de la glycogénogénèse hépatique, ou d'un blocage de la glycogénolyse hépatique, ou d'une accélération de la glycolyse hépatique.

L'A. arrive à la conclusion qu'on ne peut considérer demonstrée définitivement des effects insuliniques directs sur le métabolisme hépatique des carbohydrats.

On discute aussi sur le problème du méchanisme de l'action éventuelle insulinique sur l'hépatocyte.

Resumen

Es presentada una reseña sintáctica de la investigaciones con las cuales se ha intentado de demostrar un efecto directo de la insulina sobre el recambio de los carbohidratos en el hígado, en el sentido de una aceleración de la glicogenogenesis hepática, o de un bloque de la glicogenolisis hepática, o de una aceleración de la glicolisis hepática.

Se concluye que efectos insulínicos directos sobre el metabolismo hepático de los carbohidratos, si bien verosímiles, no pueden ser considerados definitivamente demostrados.

Se menciona también el problema del mecanismo de la eventual acción insulínica sobre la hepatocidad.

Zusammenfassung

Es wird eine synthetische Rundschau der Forschungen vorgestellt, mit welchen man versuchte, einen direkten Effekt des Insulins auf den Kohlehydratstoffwechsel in der Leber, im Sinne einer Beschleunigung der Leberglykogenese, einer Hemmung der Leberglykogenolyse oder einer Beschleunigung der Leberglykolyse nachzuweisen.

Es wird die Schlussfolgerung gezogen, dass direkte Insulineffekte auf den Leberstoffwechsel der Kohlehydrate nicht als endgueltig bewiesen betrachtet werden koennen, auch wenn sie wahrscheinlich sind.

Es wird auch das Problem des Mechanismus der eventuellen Insulinwirkung auf den Hepatozyten angeschnitten.

Summary

A synthetic review on the researches by means of which it has been attempted to show a direct action of insulin on the carbohydrate metabolism of the liver is presented: insulin could act quickening the hepatic glycogenogenesis, stopping the hepatic glycogenolysis or quickening the hepatic glycolysis.

The A. comes to the conclusion that insulin action on the carbohydrate metabolism of the liver cannot be considered definitely proved, though probable.

The question of the manner of the possible insulin action on liver cells is mentioned too.

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Bibliografia

  1. Abd-el-Rahman M. J., Mucci A., Morcos R., Petzold R., Macht G., Ditschuneit H., Pfeiffer E. F.: Der Einfluss der Leber auf die Transportform von endogenem Insulin und die Wirkung von endogenem Insulin auf den Leberzellstoffwechsel - X° Congr. Soc. Ted. Endocr., Vienna3 3, 1963.

    Google Scholar 

  2. Antoniades H. N.: Studies on the State of Insulin in Blood: the State and Transport of Insulin in Blood - Endocrinology68 7, 1961.

    PubMed  Google Scholar 

  3. Antoniades H. N., Bougas J. A., Pyle H. N.: Studies on the State of Insulin in Blood: Examination of Splenic, Portal and Peripheral Human Blood Sera of Diabetic and non Diabetic Subjects for «Free» Insulin and Insulin Complexes - New Engl. J. Med.267 218, 1962.

    Google Scholar 

  4. Bearn A. G., Billing B. H., Sherlock S.: Hepatic Glucose Output and Hepatic Insulin Sensitivity in Diabetes Mellitus - Lancet2 698, 1951.

    PubMed  Google Scholar 

  5. Berson S. A., Yalow R. S., Baumann A., Rotschild M. A., Newerly K.: (citati daCameron J. S.)10 - J. clin. Invest.35 170, 1956.

    PubMed  Google Scholar 

  6. Berthet J., Jaques P., Henneman G., De Duve C.: Influence hormonale sur la synthèse de glycogene hepatique in vitro - Arch. int. Physiol.62 282, 1954.

    Google Scholar 

  7. De Bodo R. C., Altszuler N., Dunn A., Steele R., Armstrong D. T., Bishop J. S.: Effects of Exogenous and Endogenous Insulin on Glucose Utilization and Production - Ann. N.Y. Acad. Sci.82 431, 1959.

    PubMed  Google Scholar 

  8. Cahill G. F. Jr.,Ashmore J., Earle H. S., Zottu S.: Glucose Penetration into Liver -Amer. J. Physiol.192 491, 1958.

    PubMed  Google Scholar 

  9. Cahill G. F. Jr.,Ashmore J., Renold A. E., Hastings A. B.: Blood Glucose and the Liver - Amer. J. Med.26 264, 1959.

    PubMed  Google Scholar 

  10. Cameron J. S.: The Effect of Insulin on Carbohydrate Metabolism in the Mammalian Liver: A Review - Guy's Hosp. Rep.3 2, 1962.

    Google Scholar 

  11. Chain E. B., Beloff-Chain A., Pocchiari F.: Attuali conoscenze sul meccanismo d'azione dell'insulina. In:Tria E.: «Il diabete: attualità e aggiornamenti» - Abruzzini Ed., Roma, 1957, pag. 252.

    Google Scholar 

  12. Chernick S. S., Chaikoff I. L.: (citati daCameron J. S.)10 -J. biol. Chem.188 389, 1951.

    PubMed  Google Scholar 

  13. Combes B., Adams R. H., Strickland W., Madison L. L.: The Physiological Significance of the Secretion of Endogenous Insulin into the Portal Circulation: IV Hepatic Uptake of Glucose during Glucose Infusion in non Diabetic Dogs - J. clin. Invest.40 1706, 1961.

    PubMed  Google Scholar 

  14. Ditschuneit H.: Transport und Bindung von Insulin im Blut - I° Simp. Internaz. sul Diabete, Modena 21–22 Settembre 1963.

  15. Dunn D. F., Friedmann B., Maas A. R., Reichard G. A., Weinhouse S.: Effects of Insulin on Blood Glucose Entry and Removal Rates in Normal Dogs - J. biol. Chem.225, 225, 1957.

    PubMed  Google Scholar 

  16. De Duve C., De Nayer P. P., De Keyser J., Bouckaert J. P. - Arch. int. Pharmacodyn.70 383, 1945 eDe Duve C., Hers H. G., Bouckaert J. P. ibidem72, 45, 1946 citati daDe Duve C.: The Hepatic Action of Insulin - Ciba Foundation Colloquia on Endocrinology9, 203, 1956.

    Google Scholar 

  17. Genes S. G., Charnaya P. M., Yurcenko M. Z.: Effect of Insulin, Chlorpropamide and Chlorisopropamide on Homeostatic Function of the Liver and on Passage of Blood Sugar into the Portal System - Fiziologischeskii Zhurnal SSSR9 1113, 1962.

    Google Scholar 

  18. Gundersen K.: The Problem of Insulin in Blood - Diabetes1 69, 1962.

    Google Scholar 

  19. Henderson M. J., Wrenshall G. A., Odense P.: Effects of Insulin on Rates of Glucose Transfer in the Depancreatized Dog - Canad. J. Biochem.33 926, 1955.

    PubMed  Google Scholar 

  20. Lamprecht W., Trautschold J.: Nachweis eines direkten Insulineffektes auf den Kohlenhydratstoffwechsel der Leber - Hoppe-Seylers Zeitschrift für physiol. Chemie311 245, 1958.

    Google Scholar 

  21. Lang S., Goldstein M. S., Levine R.: Influence of the Liver on Uptake of Glucose by Extrahepatic Tissues - Amer. J. Physiol.177 447, 1954.

    PubMed  Google Scholar 

  22. Lee N. D., Wisemann R. Jr.: The Significance of the Binding of Insulin I131 to Cytostructural Elements of Rat Liver - Endocrinology65 442, 1959.

    PubMed  Google Scholar 

  23. Leonards J. R., Landau B. R., Craig J. W., Martin F. J., Miller M., Barry F. M.: Regulation of Blood Glucose Concentration - Hepatic Action of Insulin - Amer. J. Physiol.201 47, 1961.

    PubMed  Google Scholar 

  24. Levine R., Goldstein M. S.: On the Mechanism of Action of Insulin -Recent. Progr. Hormone Research.11 343, 1955.

    Google Scholar 

  25. Levine R., Fritz J. B.: The Relation of Insulin to Liver Metabolism -Diabetes5 209, 1956.

    PubMed  Google Scholar 

  26. Madison L. L., Unger R. H.: The Physiological Significance of the Secretion of Endogenous Insulin into the Portal Circulation - J. clin. Invest.37 631, 1958.

    PubMed  Google Scholar 

  27. Madison L. L., Unger R. H., Rencz K.: The Physiological Significance of Secretion of Insulin into Portal Circulation: II Effect of Rate of Administration of Glucagon free Insulin on Magnitude of Peripheral and Hepatic Actions - Metabolism9 97, 1960.

    PubMed  Google Scholar 

  28. Mahler R. F., Shoemaker W. C., Ashmore J.: Hepatic Action of Insulin - Ann. N. Y. Acad. Sci.82 452, 1959.

    PubMed  Google Scholar 

  29. Marble A., Cahill G. F.: The Chemistry and Chemotherapy of Diabetes Mellitus - Tomas Ed., Springfield, Ill. U.S.A. 1962, pag. 54.

    Google Scholar 

  30. Meythaler F., Stahnke E.: Die Wirkung des Pankreashormons bei experimenteller Umgehung der physiologischen Leberpassage - Arch. Exp. Path. Pharmak.152 185, 1930.

    Google Scholar 

  31. Mucci A., Abd-el-Rahman M. J., Hellenbrecht D., Ditschuneit H., Pfeiffer E. F.: Aspetti dell'azione insulinica sul metabolismo glicidico del fegato - Com. I° Simp. Internaz. sul diabete, Modena, 21–22 settembre 1963.

  32. Mucci A., Lucchi R.: Il problema dell'insulina nel sangue -Boll. Soc. med. chir., Modena,52 1, 1962.

    Google Scholar 

  33. Renold A. E., Hastings A. B., Nesbett F. B., Ashmore J.: Studies in Carbohydrate Metabolism in Rat Liver Slices - IV Biochemical Sequence of Events after Insulin Administration- J. biol. Chem.213 135, 1955.

    PubMed  Google Scholar 

  34. Searle G. L., Chaikoff J. L.: (citati daCameron J. S.)10 -Amer. J. Physiol.170 456, 1952.

    PubMed  Google Scholar 

  35. Shoemaker W. C., Mahler R. F., Ashmore J.: The Effect of Insulin on Hepatic Glucose Metabolism in the Unanestethized Dog - Metabolism8 494, 1959.

    PubMed  Google Scholar 

  36. Shoemaker W. C., Carruthers P. J., Powers I. C., Yanof H. M.: Hepatic Effect of Insulin in Unanesthetized Normal, Diabetic and Adrenalectomized Dogs - Amer. J. Physiol.201 804, 1961.

    PubMed  Google Scholar 

  37. Steiner D. F., Randa V., Williams R. H.: Effect of Insulin, Glucagon, and Glucocorticoids upon Hepatic Glycogen Synthesis from Uridine Disphosphate Glucose - J. biol. Chem.234 299, 1961.

    Google Scholar 

  38. Viñuela E., Salas M., Sols A.: Glucokinase and Hexokinase in Liver in Relation to Glycogen Synthesis - J. biol. Chem.238 1175, 1963.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Istituto di Clinica Medica Generale e Terapia Medica, dell'Universita' di Modena, Italy

    Angelo Mucci

  2. Via V. Bellini, 210, Modena, Italy

    Angelo Mucci

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Mucci, A. Considerazioni sull'azione dell'insulina sul metabolismo dei carboidrati nel fegato. Acta diabet. lat 2, 500–506 (1965). https://doi.org/10.1007/BF01457122

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