Abstract
During the peri- and early postnatal period, nephrogenesis is completed and kidney growth is accomplished both by cellular proliferation and enlargement. The number of nephrons in a given species is predetermined, whereas cellular growth can be influenced by environmental factors in an age-dependent manner. Unilateral nephrectomy or a high-protein diet stimulates renal growth more in the young than in the adult. Conversely, pyelonephritis inhibits renal growth in infancy but not in adulthood. The relative importance of hyperplasia and hypertrophy for renal growth also changes with renal maturation. The mechanisms behind these developmental changes in regulation of renal growth are largely unknown, but age-dependent changes in the expression of several proto-oncogene products have been demonstrated. These include growth factor receptors as well as components of the intracellular system that transfers the signal from an activated growth factor receptor to the cell nucleus. Studies on rat proximal tubule cells in primary culture might be of great value in expanding our knowledge of growth regulation in the developing kidney. Such studies have already shown that under identical environmental conditions the basal proliferative rate is age dependent, that the proliferative response to growth stimulation changes postnatally, and that this is associated with changes of both the response of the Na+/H+-exchanger and the expression of the c-fos proto-oncogene.
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References
Wikstad I, Aperia A, Broberger O, Ekengren K (1979) Vesicoureteric reflux and pyelonephritis. Acta Radiol Diagn 20: 252–260
Wikstad I, Aperia A, Broberger O, Löhr F (1981) Long-time effect of large vesicoureteral reflux with or without urinary tract infection. Acta Radiol Diagn 22: 325–330
Potter EL (ed) (1972) Normal and abnormal development of the kidney. Year Book Medical, Chicago
Larsson L, Aperia A, Wilton P (1980) Effect of normal development on compensatory renal growth. Kidney Int 18: 29–35
Schwartz GJ, Evan AP (1984) Development of solute transport in rabbit proximal tubule. III. Na−K-ATPase activity. Am J Physiol 246: F845-F852
Larsson SH, Rane S, Fukuda Y, Aperia A, Lechene C (1990) Changes in Na influx precede postnatal increase in Na, K-ATPase activity in rat renal proximal tubular cells. Acta Physiol Scand 138: 99–100
Baum M (1990) Neonatal rabbit juxtamedullary proximal convoluted tubule acidification. J Clin Invest 85: 499–506
Celsi G, Jakobsson B, Aperia A (1986) Influence of age on compensatory renal growth in rats. Pediatr Res 20: 347–350
Larsson SH, Yun S, Kölare S, Aperia A (1990) Postnatal changes in growth of rat proximal tubule cells: a study of cells in short primary culture. Acta Physiol Scand 138: 243–244
Mendley SR, Toback FG (1989) Autocrine and paracrine regulation of kidney epithelial cell growth. Annu Rev Physiol 51:33–50
Fisher DA, Salido EC, Barajas L (1989) Epidermal growth factor and the kidney. Annu Rev Physiol 51: 67–80
Lajara R, Rotwein P, Bortz JD, Hansen VA, Sadow JL, Betts CR, Rogers SA, Hammerman MR (1989) Dual regulation of insulin-like growth factor I expression during renal hypertrophy. Am J Physiol 257: F252-F261
Roberts AB, Sporn MB (1988) Transforming growth factor beta. Adv Cancer Res 51: 107–145
Norman J, Badie-Dezfooly B, Nord EP, Kurtz I, Schlosser J, Chaudhari A, Fine LG (1987) EGF-induced mitogenesis in proximal tubular cells: potentiation by angiotensin II. Am J Physiol 253: F299-F309
Larsson SH, Fukuda Y, Kölare S, Aperia A (1990) Proliferation and intracellular pH in cultured proximal tubular cells. Am J Physiol 258: F697-F704
Grinstein S, Rotin D, Mason MJ (1989) Na+/H+-exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta 988: 73–97
Larsson SH, Ekblad H, Aperia A (1990) The capacity of Na+/H+ exchange in proximal tubule cells (PTC) increases during postnatal maturation. J Am Soc Nephr 1 (4): 653
Verma IM, Mitchell RL, Sassone-Corsi P Proto-oncogene fos: an inducible gene. Int Symp Princess Takamatsu Cancer Res Fund 1986; 17: 279–290
Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M (1988) The c-fos protein interacts with c-jun/AP1 to stimulate transcription of AP-1 responsive genes. Cell 54: 541–552
Adamson ED (1987) Oncogenes in development. Development 99: 449–471
Larsson SH, Hultgårdh-Nilsson A, Kölare S, Luthman J, Sejersen T, Aperia A (1991) Serum factors induce c-fos expression and rapid cell proliferation in adolescent but not in infant rat proximal tubule cells. Pediatr Res 29 (3): 263–267
Celsi G, Larsson L, Aperia A (1986) Proximal tubular reabsorption and Na−K-ATPase activity in remnant kidney of young rats. Am J Physiol 251: F588-F593
Fine LG (1986) The biology of renal hypertrophy. Kidney Int 29: 619–634
Jakobsson B, Celsi G, Lindblad BS, Aperia A (1987) Influence of different protein intake on renal growth in young rats. Acta Paediatr Scand 76: 293–299
Jakobsson B, Boman S-O, Sundelin B, Aperia A (1988) Mitotic response to high protein intake in different renal cell types in weanling rats. Kidney Int 33: 662–666
Wikstad I, Hannerz L, Karlsson A, Eklöf A-C, Olling S, Aperia A (1990)99mTC-DMSA scintigraphy in the diagnosis of acute pyelone-phritis in rats. Pediatr Nephrol 4: 331–334 (in press)
Hannerz L, Celsi G, Eklöf A-C, Olling S, Wikstad I, Aperia A (1989) Ascending pyelonephritis in young rats retards kidney growth. Kidney Int 35: 1133–1137
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Larsson, S.H., Aperia, A. Renal growth in infancy and childhood —experimental studies of regulatory mechanisms. Pediatr Nephrol 5, 439–442 (1991). https://doi.org/10.1007/BF01453677
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DOI: https://doi.org/10.1007/BF01453677