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Antineutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus

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Abstract

We aimed to evaluate the presence of peripheral antineutrophil cytoplasmic antibodies (p-ANCA) and cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) in children with SLE and to correlate its association of laboratory findings.

Twenty-one children with SLE were studied. Serum samples in patients were tested by indirect immuno-fluorescence (IIF) slide kit (INOVA) for c-ANCA and p-ANCA and by ELISA for myeloperoxidase (MPO-ANCA) and proteinase 3 (PR3-ANCA). All the patients but two were quiescent for lupus at the time of sampling

Sixteen of 21 patients showed positive IIF staining whereas only 5 had MPO-ANCA and 2 of nine PR3-ANCA.

The data suggests that SLE may be associated p-ANCA directed against additional target antigens rather than MPO and may be implicated in the pathogenesis of SLE or may be only non-specific antibodies developed in lupus.

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  1. A. Bakkaloğlu

    Present address: Department of Pediatric Nephrology and Rheumatology, Hacettepe University, School of Medicine, 06100, Ankara, Turkey

Authors and Affiliations

  1. Department of Pediatric Nephrology and Rheumatology, Hacettepe University, School of Medicine, 06100, Ankara, Turkey

    R. Topaloğlu, U. Saatçi, S. Özdemir, S. Özen, Y. Başsoy & N. Beşbaş

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  1. A. Bakkaloğlu
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  2. R. Topaloğlu
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  3. U. Saatçi
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  4. S. Özdemir
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  5. S. Özen
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  6. Y. Başsoy
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  7. N. Beşbaş
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Bakkaloğlu, A., Topaloğlu, R., Saatçi, U. et al. Antineutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus. Clin Rheumatol 17, 265–267 (1998). https://doi.org/10.1007/BF01451065

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  • DOI: https://doi.org/10.1007/BF01451065

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