Abstract
A 49-year-old man presented a clinical picture suggesting seronegative rheumatoid arthritis. He developed severe joint contractions, pasty synovial swelling, macroglossia and proteinurie. Subsequent investigations disclosed light-chain multiple myeloma and A1-amyloid deposits in synovial tissue and skin. A1-amyloidosis should be considered in the differential diagnosis of patients with seronegative polyarthritis. Clues to the diagnosis of amyloid arthropathy are a carpal tunnel syndrome, early occurrence of joint contractures in combination with a relatively mild synovitis and a low ESR as well as the presence of other possible organ involvement with amyloidosis.
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de Ruiter, E.A., Ronday, H.K. & Markusse, H.M. Amyloidosis mimicking rheumatoid arthritis. Clin Rheumatol 17, 409–411 (1998). https://doi.org/10.1007/BF01450905
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DOI: https://doi.org/10.1007/BF01450905