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Die Einwirkung massiver Kaltblutinfusion auf die Herztätigkeit beim Hund

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Zusammenfassung

Die Einwirkung massiver Infusion von kaltem (9 bis 11°C) autologem Heparinblut auf die Herztätigkeit wurde im Hundeexperiment untersucht. Die Reinfusion der zur Auslösung eines hypovolämischen Schockzustandes entzogenen Blutmenge (30 bis 40 ml/kg Körpergewicht) führte in unseren Versuchen nicht zum Herzstillstand. Wurde dagegen das gekühlte Blut in Form einer Dauerinfusion gegeben, deren Gesamtmenge das normale Blutvolumen der Versuchstiere um ein Mehrfaches überstieg, so kam es in zwei von sechs Fällen zum Herzstillstand. Die Temperatur im Myokard der rechten Herzkammer betrug beim Eintritt des Herzstillstandes 26,5° bzw. 22,0°C.

Die Problematik der raschen Transfusion großer Mengen von Citratblut wird kurz diskutiert. Es werden Richtlinien für den klinischen Gebrauch aufgestellt.

Summary

The influence of massive infusion of cooled (9 to 11°C) autologous blood on the heart was studied in the dog. The infusions were given at a rate of about 4 ml per kilogram of body weight per minute. The infusion of a quantity of blood smaller than the normal blood volume of the dog as used in the correction of oligemic shock induced by an acute blood loss did not lead to cardiac arrest in any of our cases. The infusion of a quantity of cooled blood which exceeded considerably the normal blood volume of the “patient”, however, did cause cardiac standstill in two out of six cases. The temperature of the myocardium of the right ventricle was 26,5 and 22,0°C respectively in these two cases.

The special problems arising with large transfusions of citrated bank blood are brievely discussed. The authors conclude that in massive transfusions of citrated bank blood the blood should be warmed to body temperature if ever possible. In any case the blood should be warmed after the third or fourth bottle if it must be given in a quantity exceeding 1 1/2 liters and at a rate of 100 ml per minute or faster.

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Diese Arbeit wurde durch die Hilfe des Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung ermöglicht.

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Aeberhard, P., Jenny, M. Die Einwirkung massiver Kaltblutinfusion auf die Herztätigkeit beim Hund. Arch. f. klin. Chir 315, 69–78 (1966). https://doi.org/10.1007/BF01440129

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  • DOI: https://doi.org/10.1007/BF01440129

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