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Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain ofDrosophila

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References

  • Arking, R., 1978a. Successful selection for increased longevity inDrosophila: Analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity. Exp. Gerontol. 22: 199–220.

    Google Scholar 

  • Arking, R., 1987b. Genetic and environmental determinants of longevity inDrosophila, pp. 1–22 in Evolution of Longevity in Animals: A Comparative Approach, edited by A. D. Woodhead and K. H. Thompson. Plenum Press, New York.

    Google Scholar 

  • Arking, R., S. Buck, R. A. Wells & R. Pretzlaff, 1988. Metabolic rates in genetically based long lived strains ofDrosophila. Exp. Gerontol. 23: 59–76.

    PubMed  Google Scholar 

  • Arking, R. & S. P. Dudas, 1989. A review of genetic investigations into aging processes inDrosophila. J. Amer. Geriatrics Soc. 37: 757–773.

    Google Scholar 

  • Arking, R. & R. A. Wells, 1990. Genetic alteration of normal aging processes is responsible for extended longevity inDrosophila. Develop. Genetics 11: 141–148.

    Google Scholar 

  • Arking, R., S. Buck, A. Berrios, S. Dwyer & G. T. Baker, III., 1991. Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain ofDrosophila. Develop. Genetics 12:

  • Austad, S. N., 1989. Life extension by dietary restriction in the bowl and doily spider,Frontilnela pyramitela. Exp. Gerontol. 24: 83–92.

    PubMed  Google Scholar 

  • Boetella, L. M., A Moya, M. C. Gonzalez & J.L. Mensua, 1985. Larval stop, delayed development and survival in overcrowded cultures ofDrosophila melanogaster: effect of urea and uric acid. J. Insect Physiol. 31: 179–185.

    Google Scholar 

  • Buck, S., R. A. Wells, S. P. Dudas, G. T. Baker, III, & R. Arking, 1993a. Chromosomal localization and regulation of the longevity determinant genes in a selected strain ofDrosophila melanogaster. Heredity 71: 11–22.

    PubMed  Google Scholar 

  • Buck, S., M., Nicholson, S. P. Dudas, G. T. Baker, III & R. Arking, 1993b. Larval regulation of adult longevity in a genetically selected long lived strain ofDrosophila melanogaster. Heredity 71: 23–32.

    PubMed  Google Scholar 

  • Clare, M. & L. Luckinbill, 1985. the effects of gene-environment interaction on the expression of longevity. Heredity 55: 19–29.

    PubMed  Google Scholar 

  • Clark, A. G., 1990. Genetic components of variation in energy storge inDrosophila melanogaster. Evolution 44: 637–650.

    Google Scholar 

  • Crowl, T. A. & A. P. Covich, 1990. Predator-induced lifehistory shifts in a freshwater snail. Science 247: 949–951.

    Google Scholar 

  • David, J. R., C. Bocquet, M. Arens & P. Foullet, 1976. Biological role of alcohol dehydrogenase in the tolerance ofDrosophila melanogaster to aliphatic alcohols. Utilization of an ADH-null mutant. Biochem. Genet. 14: 989–977.

    Google Scholar 

  • Dudas, S. P., 1993. Molecular genetic investigation of the extended longeveity phenotype of a long lived strain ofDrosophila melanogaster. A dissertation submitted to the Graduate School of Wayne State University, May 1993.

  • Economos, A. C. & F. A. Lints, 1984. Growth rate and life span inDrosophila. III. Effect of body size and developmental temperature on the biphasic relationship between growth rate and life span. Mech. Ageing and Develop. 27: 153–160.

    Google Scholar 

  • Everse, J., E., Zoll, L. Kahon & N. Kaplan, 1971. Addition products of diphosphopyridine nucleotides with substrates of pyridine nucleotide-linked dehydrogenases. Bioorg. Chem. 1: 207.

    Google Scholar 

  • Graf, J.-D. & F. J. Ayala, 1986. Genetic variation for superoxide dismutase level inDrosophila melanogaster. Biochemical Genetics 24: 153–168.

    PubMed  Google Scholar 

  • Graves, J. L., E. C. Toolson, C. Jeong, L. N. Vu & M. R. Rose, 1992. Dessication, flight, glycogen. and postponed senescence inDrosophila melanogaster. Physiol. Zool. 65: 268–286.

    Google Scholar 

  • Hayflick, L., 1985. Theories of biological aging. Exp. Gerontol. 20: 145–159.

    PubMed  Google Scholar 

  • Heinstra, P. W. H. & B. W. Geer, 1991. Metabolic control analysis and enzyme variation: nutritional manipulation of the flux from ethanol to lipids inDrosophila. Mol. Biol. Evol. 8: 703–708.

    PubMed  Google Scholar 

  • Hoffmann, R. N., 1989. The effects of delayed mating on components of fitness, life span, and the geotactic behavior ofDrosophila melanogaster selected for a postponed senescence. A dissertation submitted to the Graduate Faculty in Biology of the City University of New York.

  • Hoffmann, A. & P. Parsons, 1989. Selection for increased desiccation resistance inDrosophila melanogaster: additive genetic control and correlated responses for other stresses. Genetics 122: 837–845.

    PubMed  Google Scholar 

  • Hoffmann, A. & P. Parsons, 1993. Selection for adult dessication resistance inDrosophila melanogaster: Fitness components, larval resistance and stress correlations. Biol. J. Linn. Soc. 48: 43–54.

    Google Scholar 

  • King, J. J. & J. F. McDonald, 1987. Post-translational control of alcohol dehydrogenase levels inDrosophila melanogaster. Genetics 115: 693–699.

    PubMed  Google Scholar 

  • Kirkwood, T. B. L. & M. R. Rose, 1991. Evolution of senescence: late survival sacrificed for reproduction. Phil. Trans. R. Soc. Lond. (B) 332: 15–24.

    Google Scholar 

  • Lints, F. A. & C. V. Lints, 1971. Influence of preimaginal environment on fecundity and ageing inDrosophila melanogaster hybrids. II. Developmental speed and life span. Exp. Gerontol. 6: 427–445.

    PubMed  Google Scholar 

  • Lints, F. A. & H. M. Soliman (ed.), 1988.Drosophila as a model organism for ageing studies. Blackie and Son Ltd, Glasgow.

    Google Scholar 

  • Lunckinbill, L. S., R. Arking, M. J. Clare, W. C. Cirocco & S. A. Buck, 1984. Selection for delayed senescence inDrosophila melanogaster. Evolution 38: 996–1004.

    Google Scholar 

  • Luckinbill, L. S. & M. J. Clare, 1985. Selection for life span inDrosophila melanogaster. Heredity 55: 9–18.

    PubMed  Google Scholar 

  • Luckinbill, L. S., M. J. Clare, W. L. Krell, W. C. Cirocco, & P. Richards, 1987. Estimating the number of genetic elements that defer senescence inDrosophila. Evolutionary Ecology 1: 37–46.

    Google Scholar 

  • Luckinbill, L. S., J. L. Graves, A. H. Reed & S. Koetsawang, 1988. Localizing genes that defer senescence inDrosophila melanogaster. Heredity 60: 367–374.

    PubMed  Google Scholar 

  • Mayr, E., 1961. Cause and effect in biology. Science 134: 1501–1506.

    PubMed  Google Scholar 

  • Miller, R. S. & J. L. Thomas, 1958. The effects of larval crowding and body size on the longevity of adultDrosophila melanogaster. Ecology 39: 118–125.

    Google Scholar 

  • Neslund, C. M., R. A. Wells & R. Arking, 1989. Behavior genetic analysis of a long lived strain ofDrosophila melanogaster. The Gerontologist 28: 226A (abstr.).

    Google Scholar 

  • Oudman, L., W. Van Delden, A. Kamping & R. Bijlsma, 1991. Polymorphism at the Adh and αGpdh loci inDrosophila melanogaster: effects of rearing temperature on delelopmental rate, body weight, and some biochemical parameters. Heredity 67: 103–115.

    PubMed  Google Scholar 

  • Partridge, L. & K. Fowler, 1992. Direct and correlated responses to selection on age at reproduction inDrosophila melanogaster. Evolution 46: 76–91.

    Google Scholar 

  • Pearl, R., 1928. The Rate of Living. University of London Press, London.

    Google Scholar 

  • Rose, M. R., 1991. Evolutionary Biology of Aging. Oxford University Press. New York.

    Google Scholar 

  • Rose, M. R., 1984. Laboratory evolution of postponed senescence inDrosophila melanogaster Evolution 38: 1004–1010.

    Google Scholar 

  • Rose, M. R. & B. Charlesworth. A test of evolutionary theories of senescence. Nature 287: 141–142.

  • Rose, M. R. & B. Charlesworth, 1981. Genetics of life history inDrosophila melanogaster. II. Exploratory selection experiments. Genetics 97: 187–196.

    PubMed  Google Scholar 

  • Rose, M. R., L. N. Vu, S. U. Park & J. L. Graves, Jr., 1992. Selection on stress resistance increases longevity inDrosophila melanogaster. Exp. Gerontol. 27: 241–250.

    PubMed  Google Scholar 

  • Service, P. M., E. W. Hutchinson, M. D. Mackinley & M. R. Rose, 1985. Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence. Physiol. Zool. 58: 380–389.

    Google Scholar 

  • Service, P. M. 1987. Physiological mechanisms of increased stress resistence inDrosophila melanogaster selected for postponed senescence. Physiol. Zool. 60: 321–326.

    Google Scholar 

  • Service, P. M., E. W. Hutchinson & M. R. Rose. Multiple genetic mechanisms for the evolution of senescence inDrosophila melanogaster. Evolution 42: 708–716.

  • Weindruch, R., R. L. Walford, S. Fligiel & D. Guthrie, 1986. The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake. Journal of Nutrition. 116: 641–654.

    PubMed  Google Scholar 

  • Weismann, A., 1891. Essays upon Heredity and Kindred Biological Problems, 2nd ed., vol. 1. Clarendon Press, Oxford.

    Google Scholar 

  • Wells, R. A., S. Buck, R. Ali, O. Marzouq & R. Arking, 1987. Localization of the longevity genes inD. melanogaster. The Gerontologist 27: 149A. (abstr.).

    Google Scholar 

  • Zwaan, B., R. Bijlsma & R. Hoekstra, 1991. On the developmental theory of ageing. I. Starvation resistance and longevity inDrosophila melanogaster in relation to pre-adult breeding conditions. Heredity 66: 29–39.

    PubMed  Google Scholar 

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Arking, R., Dudas, S.P. & Baker, G.T. Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain ofDrosophila . Genetica 91, 127–142 (1993). https://doi.org/10.1007/BF01435993

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