Abstract
The course of coccidioidomycosis produced in mice by intranasal administration of arthrospores of COCCIDIOIDES IMMITIS was adversely affected by exposure of the animals to air containing 3–4 × 105 positive ions/cm3. A significant number of mice became ill earlier than controls and the cumulative mortality among iontreated animals was higher throughout the 30-day period of observation (difference significant at the 97.5 level by chi-square analysis).The mechanism responsible for this effect is as yet unknown.
Zusammenfassung
Der Verlauf der Coccidioidomykose bei Mäusen, die durch intranasale Verabreichung von COCCIDIOIDES IMMITIS erzeugt wurde, wurde gegensinnig beeinflusst, wenn die Tiere einer Luft mit 3–4 × 105 positiven Ionen/m3 exponiert wurden. Eine signifikante Zahl Mäuse wurde früher krank als die Kontrollen und die kumulative Mortalität der ionen-behandelten Tiere war höher während der 30-tägigen Beobachtungsperiode. Der Wirkungsmechanismus ist noch unbekannt.
Resume
L'évolution de la coccidioïdomycose déclenchée chez des souris par l'application intranasale de COCCIDIOIDES IMMITIS fut influencée de façon contradictoire lorsque les animaux étaient exposés à un air chargé de 3 à 4 × 105 ions positifs par m3. Un nombre significatif de souris furent atteintes du mal plus rapidement que celles servant de contrôle. De même,la mortalité cumulée des animaux traîtés par de l'air ionisé fut plus élevée durant les 30 jours que dura l'essai. Le mécanisme auquel cet effet doit être attribué n'est pas connu jusqu'ici.
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Krueger, A.P., Levine, H.B. The effect of unipolar positively ionized air on the course of coccidioidomycosis in mice. Int J Biometeorol 11, 279–288 (1967). https://doi.org/10.1007/BF01426650
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DOI: https://doi.org/10.1007/BF01426650