Summary
A new case of hypothalamic hamartoma associated with precocious puberty is presented. After reviewing the literature, 23 other cases appeared. The ultrastructural study of the present case revealed common features with other hamartomatous lesions of the central nervous system and with the gangliogliomas. The data suggest that these lesions are morphologically organized in a very similar manner despite their very different growing potential.
Similar content being viewed by others
References
Alvarez-Garijo, J. A., Albiach, V. J., Vila, M. M., Mulas, F., Esquembre, V., Precocious puberty and hypothalamic hamartoma with total recovery after surgical treatment. Case report. J. Neurosurg.58 (1983), 583–585.
Balagura, S., Shulman, K., Sobel, E. H., Precocious puberty of cerebral origin. Surg. Neurol.11 (1979), 315–326.
Bierich, J. R., Sexual precocity. In: Clinics in Endocrinology and Metabolism, vol. 4, pp. 107–142. Philadelphia: Saunders. 1975.
Bronstein, I. P., Luhan, J. A., Marrelis, W. B., Sexual precocity associated with hyperplastic abnormality of the tuber cinereurn. Amer. J. Dis. Child.64 (1942), 211–220.
Brouwer, B., über die Pathologie des Hypothalamus. Schw. Arch. Neurol. Psychiat.65 (1950), 35–51.
Driggs, M., Spatz, H., Pubertas praecox bei einer hyperplastischen Mißbildung des Tuber Cinereum. Virchows Arch. Path. Anat.305 (1940), 567–592.
Graber, H., Kersting, G., Pubertas praecox bei Hamartie des medio-basalen Hypothalamus mit heterotopen Retinalanlagen. Dtsch. Z. Nervenhk.173 (1955), 1–20.
Hann, J., Pubertas praecox bei hyperplastischer Mißbildung des Hypothalamus (Hamartom). Nervenarzt30 (1959), 19–27.
Hooft, C., Diericks, K., Citers, P., Pubertas praecox bei einem zweijährigen Mädchen mit einem Tumor des linken Corpus mamillare. Mschr. Kindergeneesk.21 (1943), 12–87.
Judge, D. M., Kulin, H. E., Page, R., Santen, R., Trapukdi, S., Hypothalamic hamartoma. A source of Luteinizing-Hormone-Releasing Factor in Precocious Puberty. New England J. Med.296 (1977), 7–10.
Kammer, K. S., Perlman, K., Humphreys, R. P., Howard, N. J., Clinical and surgical aspects of hypothalamic hamartoma associated with precocious puberty in a 15-month-old boy. Child's Brain6 (1980), 150–157.
Lange-Cosack, H., Verschiedene Gruppen der hypothalamischen Pubertas praecox. Dtsch. Z. Nervenhk.166 (1951), 499–545.
Le Marquand, H. S., Russell, D. S., A case of pubertas praecox (macroginetosomia praecox) in boy associated with a tumor in the floor of the third ventricle. Roy. Berkshire Hosp. Rep.35 (1934), 31–61.
Loop, J. W., Precocious puberty. Pneumoencephalography demonstrating a hamartoma in the absence of cerebral symptoms. New England J. Med.217 (1964), 409–411.
Martin, J. B., Reichlin, S., Brown, G. M., Clinical Neuroendocrinology, pp. 93–192 and 377–378. Philadelphia: Davis. 1977.
Mc Cullagh, E. P., Rosenberg, H. S., Norman, N., Tumor of the tuber cinereum with precocious puberty. Case report with hormone assays. J. Clin. Endocr. Metab.20 (1960), 1286–1293.
Meyer, J. E., Pubertas praecox bei einer hyperplastischen Mißbildung des Hypothalamus. Arch. Psychiat.179 (1948), 378–394.
Northfield, D. W. C., Russell, D. S., Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumour. J. Neurol. Neurosurg. Psychiat.30 (1967), 166–173.
Richter, R. B., True hamartoma of the hypothalamus associated with pubertas praecox. J. Neuropath. Exp. Neurol.10 (1951), 368–383.
Rubinstein, L. J., Herman, M. M., A light- and Electronmicroscopic study of a temporal-lobe ganglioglioma. J. Neurol. Sci.16 (1972), 27–48.
Stotijn, C. P., Nauta, W. J., Precocious puberty and tumor of the hypothamalus. J. Nerv. Ment. Dis.111 (1950), 207–224.
Stutte, H., Pubertas praecox bei hyperplastischer Fehlbildung des Tuber cinereum. Dtsch. Z. Nervenhk.164 (1950), 157–173.
Tanner, J. M., Growth and endocrinology of the adolescent. In: Endocrine and Genetic Diseases of Childhood and Adolescence (Gardner, L. I., eds.), pp. 14–64. Philadelphia: W. B. Saunders. 1975.
Takeuchi, J., Handa, H., Miki, Y., Munemitsu, H., Aso, T., Precocious puberty due to hyperthalamic hamartoma. Surg. Neurol.11 (1979), 456–460.
Van der Sar, A., Moffie, D., Precocious puberty due to a hypothalamic tumour (hamartoma) in negroid boy. Acta Psychiat. Neurol.35 (1960), 345–359.
Vaquero, J., Cabezudo, J. M., Leunda, G., Carrillo, R., Bravo, G., Intraorbital and intracranial glial hamartoma. Case report. J. Neurosurg.53 (1980), 117–120.
Vaquero, J., Oya, S., Ultrastructural findings in a case of nervous tissue heterotopia. Morfol. Norm. Patol. Sec. B8 (1983), 161–164.
Wolman, L., Balmforth, G. V., Precocious puberty due to a hypothalamic hamartoma. J. Neurol. Neurosurg, Psychiat.26 (1963), 275–280.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vaquero, J., Carrillo, R., Oya, S. et al. Precocious puberty and hypothalamic hamartoma. Report on a new case with ultrastructural data. Acta neurochir 74, 129–133 (1985). https://doi.org/10.1007/BF01418802
Issue Date:
DOI: https://doi.org/10.1007/BF01418802