Skip to main content
SpringerLink
Log in

Multifocal spinal angiosarcoma after chordotomy

  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

A male aged 60 is reported who, 5 years after chordotomy at the Th2/3 level, developed acute paraplegia of the legs and a sensory transverse lesion due to an extradural tumour of the Th 1–4 level. Neuropathology revealed transverse necrosis of the thoracic spinal cord (Th 1–4) due to an intradural tumour at the upper thoracic and lumbar spinal levels, the thoracic malignancy arising at the site of the previous chordotomy, with a suture being observed within the tumour mass. Histology, positive immunostaining of tumour cells with Factor VIII antigen, a specific marker of endothelial cells and the ultrastructural demonstration of Weibel-Palade bodies in endothelial cells of the tumour vessels suggested a malignant mesenchymal tumour of angiosarcoma type presumably arising from the spinal meninges, and broadly invading the spinal cord. The usual relation of this extremely rare intraspinal vasoformative malignancy to previous chordotomy is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Auster, L. S., The role of trauma in oncogenesis: a juridical consideration. J. Amer. med. Assoc.175 (1961), 946–950.

    Google Scholar 

  2. Battifora, H., Hemangiopericytoma: Ultrastructural study of five cases. Cancer31 (1973), 1418–1432.

    PubMed  Google Scholar 

  3. Bojsen-Møller, M., Knudsen, V., Radition-induced meningeal sarcoma. Acta Neurochir. (Wien)37 (1977), 147–152.

    Google Scholar 

  4. Bricklin, A. S., Rushton, H. W., Angiosarcoma of venous origin arising in the radial nerve. Cancer30 (1977), 1556–1558.

    Google Scholar 

  5. Cervós-Navarro, J., Elektronenmikroskopie der Hämangioblastome des ZNS und der angioblastischen Meningiome. Acta neuropath. (Berl.)19 (1971), 184–207.

    Google Scholar 

  6. Chaudhry, A. P., Montes, M., Cohn, G. A., Ultrastructure of cerebellar hemangioblastoma. Cancer42 (1978), 1834–1850.

    PubMed  Google Scholar 

  7. Duffy, P. E., Virus-induced cerebral sarcomas. J. Neuropath, exp. Neurol.29 (1970), 370–391.

    Google Scholar 

  8. Epstein, J. I., White, C. L., Mendelsohn, G., Factor VIII related antigen and glial fibrillary acidic protein immunoreactively in the differential diagnosis of CNS hemangioblastomas. Amer. J. Clin. Path.81 (1984), 285–292.

    Google Scholar 

  9. Guarda, L. A., Ordonez, N. G., Smith, J. L., Hanssen, G., Immunoperoxidase localization of Factor VIII in angiosarcomas. Arch. Pathol. Lab. Med.106 (1982), 515–516.

    PubMed  Google Scholar 

  10. Harris, D. L., Fornasier, V. L., Livingston, K. E., Hemangiopericytoma of the spinal canal. J. Neurosurg.49 (1978), 914–920.

    PubMed  Google Scholar 

  11. Ho, K.-L., Ultrastructure of cerebellar capillary hemangioblastoma. I. Weibel-Palade bodies and stromal cell histogenesis. J. Neuropath, exp. Neurol.43 (1984), 592–608.

    Google Scholar 

  12. Holländer, H., Koshmuolou, K., Sturm, W., Intraspinales Meningeom nach Wirbelfraktur. Zbl. Neurochir.32 (1971), 179–185.

    Google Scholar 

  13. Hüben und Kuhlendal, H., Geschwulstbildung nach Verletzungen durch elektrischen Strom. Dt. Z. Nervenheilkd.167 (1952), 421–130.

    Google Scholar 

  14. Jurco, S. III, Nadji, M., Harvey, D. G.,et al., Hemangioblastomas: Histogenesis of the stromal cells studied by immunocytochemistry. Hum. Pathol.13 (1982), 13–18.

    PubMed  Google Scholar 

  15. Kastendieck, H., Klöppel, G., Altenähr, E., Morphologie und klinische Bedeutung des meningealen Hämangioperizytoms. Z. Krebsforsch.85 (1976), 287–297.

    Google Scholar 

  16. Krämer, G., Hirntumor nach Trauma: Literaturübersicht und Begutachtungsproblematik. Akt. Neurol.9 (1982), 112–120.

    Google Scholar 

  17. Llena, J. F., Hirano, A., Inque, A., Vasoformative tumor of the brain. Immunohistology and ultrastructure. Clin. Neuropath.3 (1984), 155–159.

    Google Scholar 

  18. McComb, R. D., Jones, T. R., Pizzo, S. V., Bigner, D. D., Specificity and sensitivity of immunohistochemical detection of Factor VIII/von Willebrand factor antigen in formalin-fixed paraffin-embedded tissue. J. Histochem. Cytochem.30 (1982), 371–377.

    PubMed  Google Scholar 

  19. McComb, R. D., Jones, T. R., Pizzo, S. V., Bigner, D. D., Localization of Factor VIII/von Willebrand Factor and glial fibrillary acidic protein in glioblastoma multiforme and mixed glio-sarcomas. J. Neuropath. exp. Neurol.41 (1982), 479–189.

    PubMed  Google Scholar 

  20. Mena, H., Garcia, J. H., Primary brain sarcomas. Light and electron microscopic features. Cancer42 (1978), 1298–1307.

    PubMed  Google Scholar 

  21. Mukai, K., Rosai, J., Burgdorf, W. H., Localization of FVIIJyRAg in vascular endothelial cells using an immunperoxidase method. Amer. J. Surg. Pathol.4 (1980), 273–276.

    Google Scholar 

  22. Nunnery, E. W., Kahn, L. B., Reddick, R. I., Lippers, S., Hemangiopericytoma: A light and ultrastructural study. Cancer47 (1981), 906–914.

    PubMed  Google Scholar 

  23. Ott, G., Fremdkörpersarkome. In: Experimentelle Medizin, Pathologie und Klinik(Leuthardt, F., Schoen, R., Schwiegk, A., Studer, H., Zollinger, U., eds.) Vol. 32. Berlin: J. Springer. 1932.

    Google Scholar 

  24. Pitlyk, P. J., Dockery, M. B., Miller, R. H., Hemangiopericytoma of the spinal cord. Report of three cases. J. Neurosurg.15 (1965), 649–653.

    Google Scholar 

  25. Pitts, O. M., Powers, J. M., Hoffman, P. M., Vascular neoplasm induced in rodent CNS by murine sarcoma viruses. Lab. Invest.49 (1983), 171–182.

    PubMed  Google Scholar 

  26. Reinhardt, G., Trauma, Fremdkörper, Hirngeschwulst. Münch. med. Wschr.75 (1928), 399–401.

    Google Scholar 

  27. Rubinstein, L. J., Sarcomas of the nervous system. In: Pathology of the Nervous System (J. Minckler, ed.), Vol. 2, pp. 2144–2164. New York: Mc Graw Hill. 1971.

    Google Scholar 

  28. Rubinstein, L. J., Personal Communication. 1984.

  29. Schmitt, H. P., Trauma und Tumor: Malignes Gliom nach Stecksplitterverletzung des Gehirns. Fortschr. Neurol. Psychiat.51 (1983), 227–231.

    PubMed  Google Scholar 

  30. Schrantz, J. L., Aroaz, C. A., Radiation induced meningial fibrosarcoma. Arch. Path. (Chic.)93 (1972), 26–31.

    Google Scholar 

  31. Slowik, F., Jellinger, K., Gaszo, L., Fischer, J., Gliosarcomas: Histological, immunohistochemical, ultrastructural, and tissue culture studies. Acta neuropath. (Berl.)67 (1985), 201–210.

    Google Scholar 

  32. Spence, A. M., Rubinstein, L. J., Cerebellar capillary hemangioblastomas. Its histogenesis studied by organ and electronmicroscopy. Cancer35 (1975), 326–341.

    PubMed  Google Scholar 

  33. Sternberger, L. A., Immunocytochemistry, 2nd Ed. New York: J. Wiley & Sons. 1979.

    Google Scholar 

  34. Tiberin, P., Maor, E., Zaizov, R., Cohen, I. J.,et al., Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. J. Neurosurg.61 (1984), 772–776.

    PubMed  Google Scholar 

  35. Troost, D., Tulleken, C. A. F., Malignant glioma after bombshell injury. Clin. Neuropath.3 (1984), 139–142.

    Google Scholar 

  36. Weibel, E. R., Palade, G. E., New cytoplasmic components in arterial endothel. J. Cell. Biol.23 (1964), 101–112.

    PubMed  Google Scholar 

  37. Witzmann, A., Jellinger, K., Weiss, R., Glioblastoma multiforme nach Kopfschuß. Neurochir. (Stuttg.)24 (1981), 202–206.

    Google Scholar 

  38. Zülch, K. J., Mennel, H. D., Gehirntumor und Trauma. Hefte Unfallheilk.107 (1970), 33–44.

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. K. Jellinger

    Present address: L. Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Wien, Austria

Authors and Affiliations

  1. Department of Neurology, Wilhelminenspital der Stadt Wien, Wien, Austria

    W. Kristoferitsch

Authors
  1. W. Kristoferitsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Jellinger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kristoferitsch, W., Jellinger, K. Multifocal spinal angiosarcoma after chordotomy. Acta neurochir 79, 145–153 (1986). https://doi.org/10.1007/BF01407459

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01407459

Keywords

Search

Navigation