Summary
Hormonal disturbances caused by hypothalamic pathology can be treated effectively by target hormone replacement in the case of failure of glandotropic hormone secretion. Hyposomatotropism in children has to be substituted by parenteral administration of growth hormone. In addition gonadotropins respectively gonadotropin releasing factor have to be given in order to restore fertility in hypothalamic hypogonadism. Posterior pituitary failure can be adequately replaced by administration of analogues of antidiuretic hormone.
Hypothalamic pathology causing hypersecretion of anterior pituitary hormones may also be accessable to medical treatment. This pertains particularly to hyperprolactinemia and precocious puberty. However, there is no medical therapy so far for hypothalamic disturbances leading to veterative dysfunction like disturbances of temperature regulation and control of thirst and polyphagia. In this situation symptomatic correction of the abnormality represents the only possibility to keep these patients alive.
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Borges, J. L. C., Gelato, M. C., Rogol, A. D., Vance, M. L., MacLeod, R. M., Loriaux, D. L., Rivier, J., Blizzard, M. R., Furlanetto, R., Evans, W. S., Kaiser, D. L., Merriam, G. R., Spiess, J., Vale, W., Thorner, M. O., Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. LancetII (1983), 119–123.
Greenspan, F. S., Forsham, P. H., Basic and clinical endocrinology. Los Altos, California: Lange Medical Publications. 1983.
Hoffman, A. R., Crowley, W. F., Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropinreleasing hormone. N. Engl. J. Med.307 (1982), 1237–1241.
Leyendecker, G., Wildt, L., Die pulsatile Therapie mit Gonadotropin-Releasinghormon (Gn-RH). Geburtsh. u. Frauenheilk.42 (1982), 689–699.
Mansfield, J. M., Beardsworth, D. E., Loughlin, J. S., Crawford, J. D., Bode, H. H., Rivier, J., Vale, W., Kushner, D. C., Crigler, J. F., Crowley, W. F., Long-term treatment of central precocious puberty with a long-acting analogue of luteinizing hormonerelease hormone. N. Engl. J. Med.309 (1983), 1286–1290.
Müller, O. A., Eversmann, T., von Werder, K., Bise, K., Müller-Höcker, J., M. Hodgkin mit suprasellärem Infiltrat. Verhandl. Deutsch. Ges. Neurologie, Vol. 2 (Seitz, D., Vogel, P., Hrsg.), S. 346–349. Berlin-Heidelberg-New York-Tokyo: Springer. 1983.
Plum, F., Van Uitert, R., Non-endocrine diseases and disorders of the hypothalamus. In: The hypothalamus (Reichlin, S.,et al., eds.), pp. 415–473. New York: Raven Press. 1978.
Rjosk, H. K., Fahlbusch, R., von Werder, K., Primäre hyperprolaktinämische Amenorrhoe. Diagnostik und Therapie. In: Fortschritte der Fertilitätsforschung (Schirren, C.,et al., eds.), pp. 281–286. Berlin: Grosse-Verlag. 1980.
Von Werder, K., Eversmann, T., Therapie des männlichen hypogonadotropen Hypogonadismus durch pulsatile Gn-RH-Applikation. Deutsch. Med. Wschr.109 (1984), 432–434.
Von Werder, K., Eversmann, T., Rjosk, H. K., Fahlbusch, R., Treatment of Hyperprolactinemia. In: Frontiers in neuroendocrinology (Ganong, W. F., Martini, L., eds.), pp. 123–159. New York: Raven Press. 1982.
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von Werder, K., Müller, O.A. Medical therapy of hypothalamic diseases. Acta neurochir 75, 147–151 (1985). https://doi.org/10.1007/BF01406335
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DOI: https://doi.org/10.1007/BF01406335