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The relation between intracranial pressure, mean arterial pressure and cerebral blood flow in patients with severe head injury

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Summary

In patients with severe head injuries ICP, MAP and CBF were measured continuously. In most patients there was a positive vasopressor response to increasing ICP, but the ICP/MAP ratio varied considerably in individual cases.

CBF was diminished either by increasing ICP or by decreasing MAP. This effect was more marked with ICP above 40 mm Hg or MAP below 110 mm Hg. In terminal stages there was often a negative MAP/ICP ratio accompanied by massive cerebral hyperaemia.

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Abbreviations

ICP:

intracranial pressure (mm Hg)

CBF, Flow:

cerebral blood flow (ml/min)

MAP:

mean arterial pressure (mm Hg)

CPP:

cerebral perfusion pressure (mm Hg) (difference between. MAP and ICP)

BP:

blood pressure

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Author notes

  1. W. Gobiet

    Present address: Neurochirurgische Universitätsklinik der Gesamthochschule Essen, Federal Republic of Germany

Authors and Affiliations

  1. Neurochirurgische Universitätsklinik der Gesamthochschule Essen, Federal Republic of Germany

    W. Grote & W. J. Bock

Authors
  1. W. Gobiet
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  2. W. Grote
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  3. W. J. Bock
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Additional information

This work was supported in part by a grant from the „Deutsche Forschungsgemeinschaft“.

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Gobiet, W., Grote, W. & Bock, W.J. The relation between intracranial pressure, mean arterial pressure and cerebral blood flow in patients with severe head injury. Acta neurochir 32, 13–24 (1975). https://doi.org/10.1007/BF01405899

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