Cerebrovascular response to changes of cerebral venous pressure and cerebrospinal fluid pressure

Summary

Using parietal cranial windows and multichannel videoangiometry, pial vessel responses were studied in cats during stepwise elevation of superior sagittal sinus pressure (P_SSS) to a level of 50 mmHg or reduction of CSF-pressure (P_CSF). P_CSF was monitored via a needle in the great cistern, known from previous studies to be identical to supratentorial CSF-pressure. During elevation of P_SSS, large and small pial veins dilated by 14±6.1% from resting diameter. Small arteries remained unresponsive until they were dilated by 9±2.1% at the level of P_SSS 50mmHg. Large arteries dilated by 18±5.5% at the level of P_SSS 50 mmHg. P_SSS was always approximately twice as high as P_CSF during increase of P_SSS. During reduction of P_CSF to

− 5 mmHg, pial veins also dilated, by 7.4±1 % on the average. This observation suggests that normal P_CSF is a result of mainly venous vascular pressure, and that the level of normal venous pressure is not dictated by P_CSF but by the function and architecture of the cerebral vasculature. Since the rapid reduction of cerebral perfusion pressure CPP by elevation of venous pressure does not induce autoregulatory adjustment according to the level of CPP, but to the level of arterial transmural pressure, it is concluded, that the basic mechanism underlying autoregulation of CBF is myogenic.