Skip to main content
SpringerLink
Log in

Homologous controlled-viscosity fibrin for endovascular embolization

Part II: Catheterization technique, animal experiments

  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

Part I of the present paper described the development of a substance for endovascular embolization from homologous fibrinogen, aprotinin, thrombin, metrizamide and CaCl2. Part II deals with the applicability of a controlled-viscosity fibrin mixture via different types of arterial catheters. In a flow-dynamic model the embolizing medium injected via a double syringe was shown to block a blood flow corresponding approximately to the flow encountered in cerebral angioma vessels.

In the course of animal experiments the embolization of mesenteric arteries of rabbits showed the distribution of the embolizing medium to be dependent on its viscosity; the action of an embolizing medium applied by means of a double syringe was studied in the femoral arteries of rabbits. Scintigraphy was used to study the distribution of the substance in the body of the experimental animal after intravenous (i.v.) application; long-term studies of embolized auricular arteries in rabbits revealed parchment-like necroses after 5 to 10 days and the presence of radiopaque substances in the ear stumps after 6 weeks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Berenstein, A., Kricheff, I. I., Catheter and material selection for transarterial embolization, technical considerations. Part I and II. Neuroradiology132 (1979), 619–639.

    Google Scholar 

  2. Berenstein, A., Technique of catheterization and embolization of the lenticulostriate arteries. J. Neurosurg.54 (1981), 783–789.

    PubMed  Google Scholar 

  3. Czirják, S., Pásztor, E., Lázár, L., Deák, G., Lányi, F., Significance of balloon catheter selective and superselective angiography in the diagnosis of cerebral vascular malformations. Acta neurochir. (Wien)58 (1981), 85–89.

    Google Scholar 

  4. Cromwell, L. D., Harris, A. B., Treatment of cerebral artenovenous malformations, a combined neurosurgical and neuroradiological approach. J. Neurosurg.52 (1980), 705–708.

    PubMed  Google Scholar 

  5. Djindjian, R., Cophignon, J., Théron, J., Merland, J. J., Houdart, R., Embolization by superselective arteriography from the femoral route in neuroradiology; review of 60 cases. Neuroradiology6 (1973), 20–26.

    PubMed  Google Scholar 

  6. Djindjian, R., Superselective internal carotid arteriography and embolization. Neuroradiology9 (1975), 145–156.

    PubMed  Google Scholar 

  7. Dotter, C. T., Goldman, M. L., Rösch, J., Instant selective arterial occlusion with isobuthyl-cyanoacrylate. Radiology114 (1975), 227–230.

    PubMed  Google Scholar 

  8. Günther, R., Klose, K., Thelen, M., Jacobi, G., Superselektive Embolisation mit Gewebekleber im Urogenitaltrakt. Fortschr. Röntgenstr.134 (1981), 536–539.

    Google Scholar 

  9. Hilal, S. K., Michelsen, J. W., Therapeutic percutaneous embolization for extra-axial vascular lesions of the head, neck, and spine. J. Neurosurg.43 (1975), 275–287.

    PubMed  Google Scholar 

  10. Ingenor, F-75020 Paris, personal communication.

  11. Kerber, C., Balloon catheter with a calibrated leak. Radiology120 (1976), 547–550.

    PubMed  Google Scholar 

  12. Laine, R., Jomin, M., Clarisse, J., Combelles, G., Les malformations artérioveneuses cérébrales profondes. Neurochirurgie27 (1981), 147–160.

    PubMed  Google Scholar 

  13. Lehman, R. A. W., Hayes, G. J., The toxicity of alkyl 2-cyanoacrylate tissue adhesives: Brain and blood vessels. Surgery61 (1967), 915–922.

    PubMed  Google Scholar 

  14. Luessenhop, A. J., Kachmann, R., Shevlin, W., Ferrero, A. A., Clinical evaluation of artificial embolization in the management of large cerebral arteriovenous malformations. J. Neurosurg.23 (1965), 400–417.

    Google Scholar 

  15. Luessenhop, A. J., Mujica, P. H., Embolization of segments of the circle of Willis and adjacent branches for management of certain inoperable cerebral arteriovenous malformations. J. Neurosurg.54 (1981), 573–582.

    PubMed  Google Scholar 

  16. Matras, H., Jesch, W., Kletter, G., Dinges, H. P., Spinale Duraklebung mit Fibrinkleber. Wien. klin. Wschr.90 (1978), 419–425.

    PubMed  Google Scholar 

  17. Merland, J. J., Riche, M. C., Chiras, J., Bories, J., Therapeutic angiography in neuroradiology. Classical data, recent advances and perspectives. Neuroradiology21 (1981), 111–121.

    PubMed  Google Scholar 

  18. Nornes, H., Grip, A., Hemodynamic aspects of cerebral arteriovenous malformations. J. Neurosurg.53 (1980), 456–464.

    PubMed  Google Scholar 

  19. Parkinson, D., Bachers, G., Arteriovenous malformations. J. Neurosurg.53 (1980), 285–299.

    PubMed  Google Scholar 

  20. Picard, L., André, J. M., Roland, J., Montaut, J., Lepoire, J., Arnould, G., Kissel, P., L'embolization; intérêt et indications en oto-neuro-ophtalmologie. Oto-Neuro-Opht.47 (1975), 79–89.

    Google Scholar 

  21. Picard, L., André, J. M., Roland, J., Sigiel, M., Montaut, J., Lepoire, J., L'embolisation dans les malformations vasculaires méningo-cranio-cutanées complexes. J. Neuroradiologie2 (1975), 233–256.

    Google Scholar 

  22. Picard, L., Even, J., Bertrand, A., Floquet, J., Yvroud, E., Folcher, J., Sigiel, M., Marchal, A. L., l'Espérance, G., Roland, J., Embols plastiques fluides. J. Neuroradiology4 (1977), 385–398.

    Google Scholar 

  23. Rassweiler, J., Kauffmann, G. W., Rohrbach, R., Richter, G., Kapilläre Embolisation, Teil I: Verschluß des gesamten arteriellen Gefäßsystems der gesunden Rattenniere. Fortschr. Röntgenstr.133 (1980), 644–653.

    Google Scholar 

  24. Redl, H., Schlag, G., Dinges, H., Kuderna, H., Seelich, T., Background and methods of “Fibrin Sealing”. Proc. of the 1st World Biomaterial Congress (Winter, G. D., ed.). Chichester: Wiley Lim. 1981.

    Google Scholar 

  25. Richling, B., Ascherl, R., Blümel, G., Endovascular embolization with homologous fibrin; long-term studies. In preparation.

  26. Richter, G., Rohrbach, R., Kauffmann, G. W., Raßweiler, J., Kapilläre Embolisation, Teil II: Verschluß des gesamten arteriellen Gefäßsystems experimentell erzeugter Nierentumoren. Fortschr. Röntgenstr.135 (1981), 85–97.

    Google Scholar 

  27. Sano, K., Jimbo, M., Saito, I., Basugi, N., Artificial embolization of inoperable angioma with polymerizing substance. In: Cerebral angiomas (Pia, H. W.,et al., eds.), pp. 222–229. Berlin-Heidelberg-New York: Springer. 1975.

    Google Scholar 

  28. Seelich, T., Redl, H., Fibrinkleber, 1. Theoretischer und experimenteller Teil. In: Fibrinogen, Fibrin und Fibrinkleber (Schimpf, K., ed.), pp. 199–208. Stuttgart-New York: Schattauer. 1980.

    Google Scholar 

  29. Vinters, H. V., Debrun, G., Kaufmann, J. C., Drake, C. G., Pathology of arteriovenous malformations embolized with isobutyl-2-cyanoacrylate (bucrylate); report of two cases. J. Neurosurg.55 (1981), 819–825.

    PubMed  Google Scholar 

  30. Vlahovitch, B., Fuentes, J. M., Embolization of cerebral angiomas by catheterization of cortical arteries. Neuroradiology11 (1976), 243–248.

    PubMed  Google Scholar 

  31. White, R. I., Strandberg, J. V., Gross, C. S.,et al., Therapeutic embolization with long-term occluding agents and their effects on embolized tissues. Radiology125 (1977), 677–687.

    PubMed  Google Scholar 

  32. Wolf, K. J., Therapeutische Embolisation von Organarterien — Tierexperimentelle Untersuchungen, erste klinische Erfahrungen, Einführung eines neuen Embolisationsmaterials, Teil 1. Fortschr. Röntgenstr.128 (1978), 414–422.

    Google Scholar 

  33. Wolf, K. J., Therapeutische Embolisation von Organarterien — Tierexperimentelle Untersuchungen, erste klinische Erfahrungen, Einführung eines neuen Embolisationsmaterials, Teil 2. Fortschr. Röntgenstr.131 (1979), 511–519.

    Google Scholar 

  34. Zanetti, P. H., Sherman, F. E., Experimental evaluation of a tissue adhesive as an agent for the treatment of aneurysms and arteriovenous anomalies. J. Neurosurg.36 (1972), 72–79.

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. B. Richling

    Present address: Neurochirurgische Universitätsklinik Wien, Alser Strasse 4, A-1090, Wien, Austria

Authors and Affiliations

  1. Department of Neurosurgery, University of Vienna, Austria

    B. Richling

Authors
  1. B. Richling
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Richling, B. Homologous controlled-viscosity fibrin for endovascular embolization. Acta neurochir 64, 109–124 (1982). https://doi.org/10.1007/BF01405624

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01405624

Keywords

Search

Navigation