Summary
The clinical course preceding brain death was observed in 62 patients by frequent clinical examinations; in 44 of them the intracranial pressure was recorded continuously. In 53 patients the diagnosis of brain death was confirmed by demonstration of cessation of the brain circulation using four-vessel cerebral angiography. Sudden and gradual deterioration was found as the intracranial pressure rose to the level of the arterial blood pressure. After arteriographic documentation of brain death spinal reflexes were present in 80 per cent of the patients.
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Becker, D. P., C. M. Robert, J. R. Nelson, and E. S. Stern, An evaluation of the definition of brain death. Neurology20 (1970), 459–462.
Bergquist, E., and K. Bergström, Angiography in cerebral death. Acta Radiol.12 (1972), 283–288.
Bès, A., L. Arbus, Y. Lazorthes, M. Escande, and J. P. Marc Vergne, Hemodynamic and metabolic studies in “coma dépassé”. In: Cerebral Blood Flow, pp. 213–215. Ed. M. Brook et al. Berlin-Heidelberg-New York: Springer. 1969.
Brock, M., K. Schürmann, and A. Hadjidimos, Cerebral blood flow and cerebral death. Acta Neurochir.20 (1969), 195–209.
Bushart, W., und P. Rittmeyer, Kriterien der irreversiblen Hirnschädigung bei Intensivbehandlung. Med. Klin.64 (1969), 184–192.
Gros, C., B. Vlahovitch, P. Frèrebeau, A. Kuhner, M. Billet, G. Sahut et G. Gavand. Critères artériographiques des comas dépassés en Neuro-Chirurgie. Neuro-Chir.15 (1969), 477–486.
Hadjidimos, A., M. Brock, P. Baum, and K. Schürmann, Cessation of cerebral blood flow in total irreversible loss of brain function. In: Cerebral Blood Flow, pp. 209–212. Ed. M. Brock et al. Berlin-Heidelberg-New York: Springer. 1969.
Heilbrun, M. P., P. B. Jørgensen, and G. Boysen, Relationships between perfusion pressure and regional cerebral blood flow in patients with intracranial mass lesions. Europ. Neurol.8 (1972), 111–117.
Johnston, I. H., J. A. Johnston, and B. Jennett, Intracranial pressure changes following head injury. Lancet2 (1970), 433–436.
Jørgensen, P. B., M. P. Heilbrun, G. Boysen, A. Rosenklint, and E. O. Jørgensen, Cerebral perfusion pressure correlated with regional cerebral blood flow, EEG and aortocervical arteriography in patients with severe brain disorders progressing to brain death. Europ. Neurol.8 (1972), 207–212.
- E. O. Jørgensen, and A. Rosenklint, Brain death. Pathogenesis and Diagnosis. Acta Neurol. Scand. In print.
Langfitt, T. W., V. S. Kumar, H. E. James, and J. D. Miller, Continuous recording of intracranial pressure in patients with hypoxic brain damage. In: Brain Hypoxia. Ed. J. D. Brierley and B. S. Meldrum. London: Heinemann. 1971.
McNealy, D. E., and F. Plum, Brainstem dysfunction with supratentorial mass lesion. Neurology7 (1962), 26–48.
Mohandas, A., and S. N. Chou, Brain death. A clinical and pathological study. J. Neurosurg.35 (1971), 211–218.
Mollaret, P., et M. Goulon, Le coma dépassé. Rev. Neurol.101 (1959), 3–15.
Nornes, H., and F. Serck-Hanssen, Miniature transducer for intracranial pressure monitoring in man. Acta Neurol. Scand.46 (1970), 203–214.
Report of the ad hoc committee of the Harvard Medical School to examine the definition of brain death. A definition of irreversible coma. J. Amer. Med. Ass.205 (1968), 337–340.
Shalit, M. N., A. J. Beller, M. Feinsod, A. J. Drapkin, and A. S. Cotev, The blood flow and oxygen consumption of the dying brain. Neurol.20 (1970), 740–748.
Waltregny, A., J. Bonnal et G. Lejeune, Mort cérébral et homotransplants. Rev. Neurol.122 (1970), 406–411.
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Supported by grants from Danish Medical Research Council and F. L. Schmidt & Co's jubeleumsfond.
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Jørgensen, P.B. Clinical deterioration prior to brain death related to progressive intracranial hypertension. Acta neurochir 28, 29–40 (1973). https://doi.org/10.1007/BF01405402
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DOI: https://doi.org/10.1007/BF01405402