Summary
In the present study we found that the neurological outcome in patients anaesthetised for early clipping (up to 72 h after SAH) of a ruptured aneurysm and treated with cyclosporine A was significantly better than the neurological state of control patients without immuno-suppressive treatment.
The results justify the presumption that auto-immune reactions are involved in the deterioration of the postoperative neurological state of patients with SAH after rupture of an intracranial aneurysm. Supplementing a standard surgical and pharmacological treatment with cyclosporine A seems to reduce the undesirable neurological consequences of the immunologically, induced vascular disturbance after SAH.
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This study was approved by the Human Investigation Committee of the Warsaw Medical School (15/11/88).
Supported by Polish Academy of Sciences. Grant No WVI/Kom/ 89.
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Ryba, M., Pastuszko, M., Iwanska, K. et al. Cyclosporine a prevents neurological deterioration of patients with SAH — A preliminary report. Acta neurochir 112, 25–27 (1991). https://doi.org/10.1007/BF01402450
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DOI: https://doi.org/10.1007/BF01402450