Summary
Radiosurgery, using90Y injected directly into the cavity of cystic craniopharyngiomas produces remarkable reduction of tumour size and diminishes cyst fluid production. The authors have studied the histology of biopsy and autopsy material obtained from seven patients presented with cystic craniopharyngiomas. Histological examination was carried out before and after90Y silicate implantation. As an effect of90Y irradiation, histology of samples taken from the cyst wall revealed that the lining epithelial cell layer became destroyed and the cyst wall shrunk. Large amount of collagen fibres with focal hyaline degeneration was present. Proliferation of intimal cells and subendothelial connective tissue narrowing small vessel lumina also occurred. Considering that fibrotic tissue is more susceptible to shrink, the fibrosis induced by irradiation together with destruction of the squamous epithelium and vascular changes, might explain the reduction of the cyst volume and diminished fluid secretion after90Y treatment.
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References
Backlund EO (1972) Stereotaktik behandling av Kraniopharyngeom med intracytiskt 90Y extern Co 60 Besträling. Stockholm: Doktor-thesis
Backlund EO, Axelsson B, Bergstrand CG, Eriksson AL, Norń G, Ribbesjö E, Rähn T, Snell PO, Tallstedt L, Sääf M, Thorén M (1989) Treatment of craniopharyngiomas — the stereotactic approach in a ten to twenty-tree years' perspective. Acta Neurochir (Wien) 99: 11–19
Constantine VS, Mowry RW (1974) Selective staining of human dermal collagen II. The use of Picrosirius red F 3 BA with polarization microscopy. In: Módis L (ed) Handbuch der Histochemie, Vol II/4. Gustav Fischer Verlag, Stuttgart, p 25
Hirano A, Ghatak NR, Zimmermen HH (1973) Fenestrated blood vessels in craniopharyngioma. Acta Neuropathol (Berlin) 26: 171–177
Julow J, Lányi F, Hajda M, Simkovics M, Arany I, Tóth Sz, Pásztor E (1985) The radiotherapy of cystic craniopharyngioma with intracystic installation of90Y silicate colloid. Acta Neurochir (Wien) 74: 94–99
Julow J, Lányi F, Hajda M, Simkovics M, Szeifert GT, Tóth Sz, Pásztor E (1988) Further experiences with the radiotherapy of cystic craniopharyngioma with intracystic installation of 90-Yttrium silicate colloid. Acta Neurochir (Wien) [Suppl] 42: 113–119
Kobayashi T, Kageyama N, Yoshida Jet al (1981) Pathological and Clinical basis of the indications for treatment of craniopharyngiomas. Neurol Med Chir (Tokyo) 21: 39–47
Kramer S, McKissock W, Concannon JP (1961) Craniopharyngiomas. Treatment by combined surgery and radiation therapy. J Neurosurg 18: 217–226
Leksell L, Backlund EO, Johansson L (1967) Treatment of craniopharyngiomas. Acta Chir Scand 133: 345–350
Petito CK, de Girolami U, Earle KM (1976) Cranipharyngiomas. A clinical and pathological review. Cancer 37: 1944–1952
Sääf Met al (1989) Treatment of craniopharyngiomas — the stereotactic approach in a ten to twenty-three years' perspective. II. Psychosocial situation and pituitary function. Acta Neurochir (Wien) 99: 97–103
Strauss L, Sturm V, Georgi Pet al (1982) Radioisotope therapy of cystic craniopharyngiomas. Int J Rad Onconol Biol Phys 8: 1581–1585
Sweet WH (1979) Recurrent craniopharyngiomas: therapeutic alternatives. Clin Neurosurg 27: 206–229
Symon L, Sprich W (1985) Radical excision of craniopharyngioma. Results in 20 patients. J Neurosurg 62: 174–181
Tejera GP, Sod L, Kotsilimbas D (1986) Recurrent cystic craniopharyngioma management and course. Neurochir 29: 48–49
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Szeifert, G.T., Julow, J., Slowik, F. et al. Pathological changes in cystic craniopharyngiomas following intracavital90yttrium treatment. Acta neurochir 102, 14–18 (1990). https://doi.org/10.1007/BF01402179
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DOI: https://doi.org/10.1007/BF01402179