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The effect of indomethacin upon cerebral blood flow in healthy volunteers

The influence of moderate hypoxia and hypercapnia

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Summary

In a randomized study of healthy volunteers indomethacin bolus injection followed by continuous infusion decreased CBF from normal levels ranging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/100 g/min. These low levels were sustained during a six hour infusion period. Periods of hypoxia during inhalation of 17% oxygen and hypercapnia during inhalation of 2–4% CO2 normalized CBF.

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Authors and Affiliations

  1. Department of Anesthesiology Hjørring Municipal Hospital, Hjørring

    L. Bünemann & H. Hansen

  2. Department of Anesthesiology Ålborg Municipal Hospital, Ålborg

    K. Jensen, M. Freundlich & K. Therkelsen

  3. Department of Anesthesiology Århus University Hospital, Århus, Denmark

    G. E. Cold

Authors
  1. K. Jensen
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  2. M. Freundlich
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  3. L. Bünemann
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  4. K. Therkelsen
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  5. H. Hansen
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  6. G. E. Cold
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Jensen, K., Freundlich, M., Bünemann, L. et al. The effect of indomethacin upon cerebral blood flow in healthy volunteers. Acta neurochir 124, 114–119 (1993). https://doi.org/10.1007/BF01401132

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