Summary
Tranexamic acid as an antifibrinolytic agent has been investigated in a controlled study in patients with recent subarachnoid haemorrhage. It is concluded that tranexamic acid improves neither rebleeding rates, nor mortality. Predominantly thrombotic complications have been noted as a more serious side effect of tranexamic acid.
Similar content being viewed by others
References
Alkjaerig, N., Fletcher, A. P., Sherry, S., E-aminocaproic acid: an inhibitor of plasminogen activation. J. Biol. Chem.234 (1959), 832–837.
Andersson, L., Nilsson, J. M., AMCA, a patent haemostatic agent in urinary tract bleeding. Scand. J. Urol. Nephrol.3 (1969), 169–176.
— —, Colleen, S., Grandstrand, B., Melander, B., Role of urokinase and tissue activator in sustaining bleeding and the management thereof with EACA and AMCA. Ann. N.Y. Acad. Sci.146 (1968), 642–658.
Botterell, E. H., Lougheed, W. M., Scott, J. W., Vanderwater, S. L., Hypothermia and interruption of carotid, or carotid and vertebral circulation in the surgical management of intracranial aneurysms. J. Neurosurg.13 (1956), 1–42.
Charyton, C., Purtilo, D., Glomerulas capillary thrombosis and acute renal failure after epsilon-aminicaproic acid therapy. N. Engl. J. Med.279 (1969), 1102–1104.
Claus, A., Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta haemat. (Basel)17 (1957), 237–246.
Gorkill, Br., Earlier operation and anti-fibrinolytic therapy in the management of aneurysmal subarachnoid hemorrhage: review of recent experience in Tasmania. Med. J. Aust.1 (1974), 468–470.
Gralnick, H. R., Greipp, P., Thrombosis with epsilon-amino-caproic acid therapy. Amer. J. Clin. Pathol.56 (1971), 151–154.
Locksley, H. B., Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section V, Part II. Natural history of subarachnoid haemorrhage, intracranial aneurysm and arteriovenous malformations. J. Neurosurg.25 (1966), 321–368.
Merskey, C., Lalezari, P., Johnson, A. J., A rapid simple method for measuring fibrinolytic split products in human serum. Proc. Soc. Exp. Biol. Med.131 (1969), 871–875.
Mullan, S., Dawley, J., Antifibrinolytic therapy for intracranial aneurysms. J. Neurosurg.28 (1968), 21–23.
Naye, R. L., Thrombotic state after a haemorrhage diathesis, a possible complication of therapy with epsilon-aminocaproic acid. Blood19 (1962), 694–701.
Nibbelink, W. D., Cooperative aneurysm study. In: Cerebral Vascular Disorders, pp. 155–173 (Whisnant, J. P., Sandok, B. A., eds.). New York: Grune and Stratton. 1975.
Nilsson, J. M., Andersson, L., Björkman, S. E., Epsilon-amino-caproic acid (EACA)as a therapeutic agent based on 5 years clinical experience. Acta Med. Scand. (Suppl.)448 (1966), 5–46.
Norlén, G., Thulin, C. A., The use of antifibrinolytic substances in rupturedintracranial aneurysms. Neurochirurgia12 (1969), 100–102.
Rossum, J. v., Wintzen, A. R., Endtz, L. J., Schoen, J. H. R., Jonge, H. d., Effect of tranexamic acid on rebleeding after subarachnoid hemorrhage: a doubleblind controlled clinical trial. Ann. Neurol.2 (1977), 242–245.
Schisano, G., The use of antifibrinolytic drugs in aneurysmal subarachnoid hemorrhage. Surg. Neurol.10 (1978), 217–222.
Smith, R. R., Upchurch, J. J., Monitoring antifibrinolytic therapy in subarachnoid haemorrhage. J. Neurosurg.38 (1973), 339–343.
Sonntag, V. H. K., Stein, B. M., Arteriopathic complications during treatment of subarachnoid hemorrhage with epsilon aminocaproic acid. J. Neurosurg.40 (1974), 480–485.
Tovi, D., The use of antifibrinolytic drugs to prevent early recurrent aneurysmal subarachnoid haemorrhage. Acta Neurol. Scand.49 (1973), 163–175.
—, Thulin, C. A., Ability of tranexamic acid to cross the blood-brain barrier and its use in patients with ruptured intracranial aneurysm. Acta Neurol. Scand.48 (1972), 257–263.
Tow, D. F., Wagner, H. N., Jr., North, W. A., Detection of venous obstruction in the legs with 99mTc-albumin. J. Nucl. Med.8 (1967), 277–281.
Uttley, D., Richardson, A. E., EACA and subarachnoid hemorrhage. Lancet2 (1974), 1080–1081.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gelmers, H.J. Prevention of recurrence of spontaneous subarachnoid haemorrhage by tranexamic acid. Acta neurochir 52, 45–50 (1980). https://doi.org/10.1007/BF01400945
Issue Date:
DOI: https://doi.org/10.1007/BF01400945