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Is vascular angiopathy following intracranial aneurysm rupture immunologically mediated?

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Summary

Immunofluorescence studies showed the presence of IgM and/ or C3 in the endothelium of intracranial aneurysms in 5 out of 6 patients with subarachnoid haemorrhage (SAH). In none of them were the immune deposits found in the gyrus rectus. Cortical tissue of 4 epileptic patients which served as a control give negative results. Serum studies on femoral artery wall used as an antigenic substrate did not reveal circulating antibodies of the IgM or IgG class.

Our studies strongly suggest that the IgM and/or C3 immune deposits located in the endothelium of intracranial arteries may play a role in post SAH neurological complications.

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References

  1. Beutner EH, Kumar V, Krasny SA (1987) Defined immunofluorescence in immunodermatology. In: Beuther EH, Chorzelski TP, Kumar Vet al (eds) Immunopathology of the skin, 3rd Ed. John Wiley, New York, pp 3–40

    Google Scholar 

  2. Chyatte D, Sundt TM Jr (1984) Response of chronic experimental cerebral vasospasm to methylprednisolone and dexamenthasone. J Neurosurg 60: 932–936

    Google Scholar 

  3. Chorzelski T, Kuch J (1969) Atypical myocardial infarction in a case of pemphigus in the light of immunofluorescence studies. Clin Exp Immunol 4: 691–695

    PubMed  Google Scholar 

  4. Findlery JM, Weív BKA, Kanamaru K, Espinosa F (1989) Arterial wall changes in cerebral vasospasm. Neurosurgery 25:736–746

    PubMed  Google Scholar 

  5. Grabar P (1983) Autoantibodies and the physiolgical role of immunoglobulins. Immunol Today 4: 337–340

    Google Scholar 

  6. Handa Y, Hayashi M, Takeuchi H, Kobayashi J, Kawano H (1990) Effect of immunosuppressive drugs in the development of cerebral vasospasm after subarachnoid hemorrhage in primates. In: Sano K, Takamura K, Kassell NF, Sasaki T (eds) Proceedings of the 4th International Conference on Cerebral Vasospasm. University of Tokyo Press, Tokyo, pp 379–381

    Google Scholar 

  7. Handa Y, Hayashi M, Takeuchi H, Kabayashi H, Kawano H, Kabuto M (1991) Effect of cyclosporine on the development of cerebral vasospasm in a primate model. Neurosurgery 28: 380–386

    PubMed  Google Scholar 

  8. Handa Y, Kabuto M, Kobayashi H, Kawano H, Takeuchi H, Hayashi M (1991) The correlation between immunological reaction in the arterial wall and the time course of the development of cerebral vasospasm in a primate model. Neurosurgery 28: 542–549

    PubMed  Google Scholar 

  9. Hoshi T, Shimizu T, Kito K, Yamasaki N, Takahashi K, Takahashi M, Okada T, Kasuya H, Kitamura K (1984) Immunological study of late cerebral vasospasm in subrachnoid hemorrhage. Detection of immunoglobulins, C3, and fibrinogen in cerebral arterial walls by immunofluorescence method. Neurol Med Chir (Tokyo) 24: 647–654

    Google Scholar 

  10. Hunt J, Kassell N, Pertuiset B, Sano K, Teasdale G, De Villiers JC, Drake CG (1988) Report of the World Federation of Neurological Surgeons Committee on a universal subarachnoid hemorrhage grading scale. J Neurosurg 68: 985–986

    PubMed  Google Scholar 

  11. Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. A practical scale. Lancet 1: 480–484

    PubMed  Google Scholar 

  12. Kuch J, Chorzelski T (1968) Immunofluorescence studies in recent myocardial infarction. Pol Arch Med Wewn 41: 729–737

    PubMed  Google Scholar 

  13. Logtenberg T (1990) Properties of polyreactive natural antibodies to self and foreign antigens. J Clin Immunol 10: 137–140

    PubMed  Google Scholar 

  14. Ostergaard JR, Kreistensen, BO, Svehag SE, Teisner B, Miletic T (1987) Immune complexes and complement activation following rupture of intracranial saccular aneurysm. J Neurosurg 66: 891–897

    PubMed  Google Scholar 

  15. Pelletieri L, Carlsson CA, Lindholm L (1981) Is the vasospasm following subarachnoid hemorrhage an immunoreactive disease? Experientia 37: 1170–1171

    PubMed  Google Scholar 

  16. Pelletieri L, Nilsson B, Carlsson CA, Nilsson U (1986) Serum immunocomplexes in patients with subarachnoid hemorrhage. Neurosurgery 19: 767–771

    PubMed  Google Scholar 

  17. Peterson JW, Kwun B, Nishizawa S, Hackett JD, Zervas NT (1988) Immunoreactivity, immunosuppression, and cerebral vasospasm following SAH. Stroke 19: 132

    Google Scholar 

  18. Peterson J, Nishizawa S, Teramura A, Candia G, Bun T, Spanes A, Zervas N (1990) Calmodulin—antagonism and immunosupression in cerebral vasospasm. In: Sano K, Takakura K, Kassell NF, Sasaki T (eds) Proceedings of the 4th International Conference of Cerebral Vasospasm. University of Tokyo Press, Tokyo, pp 375–378

    Google Scholar 

  19. Peterson JW, Nishizawa S, Hackett JD, Bun T, Teramura A, Zervas NT (1990) Cyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs. Stroke 21: 133–137

    PubMed  Google Scholar 

  20. Ryan US (1989) Keynote address: active function of the endothelium. In: Ginsberg MG, Ditrich WD (eds) Cerebrovascular diseases. Raven Press, New York, pp 1–15

    Google Scholar 

  21. Ryba M, Pastuszko M, Iwańska K, Koziarski A (1989) Immunological method for prevision of the progress in neurological deficit in patients with intracranial aneurysm rupture. Acta Neurochir (Wien) 97: 67–70

    Google Scholar 

  22. Ryba M, Pastuszko M, Bidziński J, Iwańska K, Dziewięcki C (1990) Immunosuppressive treatment reduces the neurological deficit after early clipping of ruptured aneurysm. In: Sano K, Takakura K, Kassell NF, Sasaki T (eds) Proceedings of the 4th International Conference on Cerebral Vasospasm. University of Tokyo Press, Tokyo, pp 382–384

    Google Scholar 

  23. Ryba M, Iwańska K, Walski M, Pastuzko M (1991) Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits. Acta Neurochir (Wien) 108: 81–84

    Google Scholar 

  24. Ryba M, Grieb P, Bidziński J, Pastuszko M, Dziewięcki C, Iwanska K (1991) Cyclosporine A for prevention of neurological deficit following subarachnoid hemorrhage in humans. Stroke 22: 531

    Google Scholar 

  25. Ryba M, Pastuszko M, Bidziński J, Iwańska K, Dziewięcki C (1991) Cyclosporine A prevents neurological deterioration of patients with SAH—a preliminary report. Acta Neurochir (Wien) 112: 25–27

    Google Scholar 

  26. Sano K, Saito J (1978) Timing and indication of surgery for ruptured intracranial aneurysms with regard to cerebral vasospasm. Acta Neurochir (Wien) 41: 49–60

    Google Scholar 

  27. Smith RR, Clower BR, Honma Y, Cruse JM (1988) The constrictive angiopathy of subarachnoid hemorrhage: an immunopathological approach. In: Wilkins RH (ed) Cerebral vasospasm. Raven, New York, pp 247–252

    Google Scholar 

  28. Soltenburg-Didinger G, Schwarz K (1986) Brain lesions secondary to subarachnoid hemorrhage due to ruptured aneurysms. In: Cervos-Navarro J, Klatzo I, Plum F (eds) Brain microcirculation, pathology, diagnosis, therapy. An Erwin-Riesch Symposium Institute of Neuropathology, Brain, September 2–5, pp 87–91

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Authors and Affiliations

  1. Department of Neurophysiology, Medical Research Centre, Polish Academy of Sciences, Poland

    M. Ryba

  2. Department of Dermatology Medical School, Institute of Surgery Medical School, Warsaw, Poland

    M. Jarząbek-Chorzelska & T. Chorzelski

  3. Department of Neurosurgery, Institute of Surgery Medical School, Warsaw, Poland

    M. Pastuszko

Authors
  1. M. Ryba
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  2. M. Jarząbek-Chorzelska
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  3. T. Chorzelski
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  4. M. Pastuszko
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Ryba, M., Jarząbek-Chorzelska, M., Chorzelski, T. et al. Is vascular angiopathy following intracranial aneurysm rupture immunologically mediated?. Acta neurochir 117, 34–37 (1992). https://doi.org/10.1007/BF01400632

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