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Increased yield of high-titre variants ofStreptomyces glomeratus , producing anthracycline antibiotics of the beromycin group, after treatment with piasmid-curing agents

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Summary

The frequency of occurrence of melaninless asporogenous variants with higher antibiotic-producing activity in populations ofStreptomyces glomeratus, a producer of beromycins, increased by more than 100–200 times as a result of treatment with plasmid-curing agents (acridine orange or acriflavine), whereas ultraviolet light and nitrous oxide were less effective in this regard.

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Authors and Affiliations

  1. Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20, Prague 4

    M. Blumaueróva & Z. Vaněk

  2. Institute of New Antibiotics, USSR Academy of Medical-Sciences, G-21, Moscow

    T. S. Maksimova & G. F. Gause

Authors
  1. M. Blumaueróva
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  2. T. S. Maksimova
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  3. G. F. Gause
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  4. Z. Vaněk
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Blumaueróva, M., Maksimova, T.S., Gause, G.F. et al. Increased yield of high-titre variants ofStreptomyces glomeratus , producing anthracycline antibiotics of the beromycin group, after treatment with piasmid-curing agents. Biotechnol Lett 1, 337–341 (1979). https://doi.org/10.1007/BF01388189

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  • DOI: https://doi.org/10.1007/BF01388189

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