Summary
HIV-1 acquires cell membrane proteins during budding. The cell membrane proteins (CMP) profile of laboratory HIV-1 strains grown in different host cells was established, by using an immobilized antibody capture (IAC), to verify whether CMPs present on HIV-1 correlate with its host cell origin. HIV-1 grown in different cell lines incorporates cell markers such as CD3, CD19, CD14, CD31 and IL 2-R, according to the distinctive expression of these antigens on the host cells. Furthermore, also T-tropic and monocytotropic HIV-1 strains display host cell specific markers, supporting the hypothesis that virus associated CMPs are a marker of host cell origin.
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Abbate, I., Capobianchi, M.R., Fais, S. et al. Host cell antigenic profile acquired by HIV-1 is a marker of its cellular origin. Archives of Virology 140, 1849–1854 (1995). https://doi.org/10.1007/BF01384347
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DOI: https://doi.org/10.1007/BF01384347