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A new immunostimulatory complex (PICKCa) in experimental rabies: antiviral and adjuvant effects

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Summary

The activity of an immunostimulatory complex (PICKCa) which is widely used against several human diseases in China was tested in experimental rabies prophylaxis. PICKCa protected mice against peripheral infection with both fixed and wild rabies strains. It also enhanced the protective activity of an experimental rabies vaccine injected either before or after rabies infection. PICKCa enhanced both non-specific immune responses and specific immunity including antibody production and cell mediated immunity as assessed by interleukin-2 production.

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Author notes

  1. H. X. Lin

    Present address: National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China

Authors and Affiliations

  1. Rabies Unit, Institut Pasteur, Paris, France

    H. X. Lin, C. Gontier & P. Perrin

  2. Laboratory of Experimental Virology, Institut Pasteur, Paris, France

    M-F. Saron

Authors
  1. H. X. Lin
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  2. C. Gontier
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  3. M-F. Saron
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  4. P. Perrin
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Lin, H.X., Gontier, C., Saron, MF. et al. A new immunostimulatory complex (PICKCa) in experimental rabies: antiviral and adjuvant effects. Archives of Virology 131, 307–319 (1993). https://doi.org/10.1007/BF01378634

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  • DOI: https://doi.org/10.1007/BF01378634

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