Abstract
The authors evaluated the relationship between drug intake and upper gastrointestinal (GI) bleeding. The endoscopic files of the previous 2 years were reviewed and the incidence and age and sex distribution recorded. GI bleeding is indication for a high percentage of lower endoscopies and a low percentage of upper endoscopies. On the other hand, although rarer upper GI bleeding is more severe and frequently related to drug ingestion. About 50% of cases showed gastric erosions secondary to drug intake. A relation between gastric bleeding and paracetamol is considered, as is the possibility of preventing secondary severe bleeding by pharmacologic gastric protection in children with risk factors such as chronic use of other drugs or portal hypertension.
Similar content being viewed by others
References
Ament ME (1990) Diagnosis and management of upper gastrointestinal tract bleeding in the pediatric patient. Pediatr Rev 12: 107–116
Coggon D, Langman MJS, Spiegelhalter D (1982) Aspirin, paracetamol, and haematemesis and melena. Gut 23: 340–344
Holvoet J, Terriere L, Van Hee W, Verbist L, Fierens E, Hautekeete ML (1991) Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study. Gut 32: 730–734
Stevenson RJ (1985) Gastrointestinal bleeding in children. Surg Clin North Am 65: 1455–1480
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Li Voti, G., Acierno, C., Tulone, V. et al. Relationship between upper gastrointestinal bleeding and non steroidal anti-inflammatory drugs in children. Pediatr Surg Int 12, 264–265 (1997). https://doi.org/10.1007/BF01372146
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01372146