Abstract
In order that there can be confidence that DNA profile frequency estimates will not place undue bias against a defendant, 2 methods are described for estimating minimum allele frequency bounds for PCR-based loci. One approach estimates minimum allele frequencies for VNTR and STR loci using sample size and the observed heterozygosity at a locus, while the second approach, appropriate for loci typed with allele-specific oligonucleotide probes, is based only on sample size. The use of a minimum allele frequency enables compensation for sparse sampling of infrequent alleles in population databases.
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This is publication number 95-10 of the Laboratory Division of the Federal Bureau of Investigation. Names of commercial manufacturers are provided for identification only, and inclusion does not imply endorsement by the Federal Bureau of Investigation
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Budowle, B., Monson, K.L. & Chakraborty, R. Estimating minimum allele frequencies for DNA profile frequency estimates for PCR-based loci. Int J Leg Med 108, 173–176 (1996). https://doi.org/10.1007/BF01369786
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DOI: https://doi.org/10.1007/BF01369786