Summary
The respective effects of the ingestion of two different doses of calcium (500 and 1500 mg) on serum ionized calcium, intact parathyroid hormone (PTH -1-84), and the urinary excretion of 3′,5′-cyclic adenosine monophosphate (cyclic AMP) were evaluated in 15 young male adults. Ionized serum calcium and PTH 1-84 were measured before and 1 hour, 2 hours and 3 hours (P1, P2, and P3) after the oral intake of calcium. Cyclic AMP was measured in 2-hour urine samples collected before and during 4 hours after the ingestion of calcium. Similar increments in serum ionized calcium (ΔCa2+) were observed except at P3 where the ΔCa2+ was significantly (P < 0.02) higher after 1500 mg (0.088 mmol/liter) than after 500 mg of (0.062 mmol/liter). In the same way, the comparison of the PITH 1-84 concentrations showed no statistical difference except at P3 (P < 0.002). When expressed as a percentage of P0, the P1 and P2 PTH 1-84 values were more suppressed after 1500 mg than after 500 mg of calcium (Pl: -69% vs -59%;P < 0.02; P2: -66% vs −50%; P < 0.02). However, the simultaneous cyclic AMP responses (−24% vs −19%) were not significantly different. The results show that the respective maximal effects on PTH secretion and on urinary cyclic AMP of two very different oral doses of calcium are only slightly different.
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References
National Research Council, Food and Nutrition Board (1979) Recommended dietary allowances, 9th revised ed. Washington DC, National Academy of Science
Guillemant S, Kremer R, Eurin J, Prier A, Camus J-P (1979) Radiocompetitive assays for 25-bydroxy vitamin D, 24,25dihydroxy-vitamin D and 1,25-dihydroxyvitamin D in human serum. In: Norman AW, Schaeffer K, v. Herrath D (eds) Vitamin D: basic research and its clinical application. De Gruyter, Berlin, p 247
Brent GA, LeBoff MS, Seely EW, Conlin PR, Brown EM (1988) Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. J Clin Endocrinol Metab 67:944–950
D'Amour P, Palardy J, Bahsali G, Mallette LE, Deléan A, Lepage R (1992) The modulation of circulating parathyroid hormone immunoheterogeneity in man by ionized calcium concentration. J Clin Endocrinol Metab 74:525–532
Tohme JF, Bilezikian JP, Clemens TL, Silverberg SJ, Shane E, Lindsay R (1990) Suppression of parathyroid hormone secretion with oral calcium in normal subjects and patients with primary hyperparathyroidism. J Clin Endocrinol Metab 70:951–956
Horowitz M, Morris HA, Hartley TF, Need AG, Wishart J, Ryan P, Nordin BEC (1987) The effect of an oral calcium load on plasma ionized calcium and parathyroid hormone in osteoporotic postmenopausal women. Calcif tissue Int 40:130–136
Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF (1979) Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. J Clin Invest 64:729–736
Bell NH, Epstein S, Shary J, Greene V, Oexmann MJ, Shaw S (1988) Evidence of a probable role for 25-hydroxyvitamin D in the regulation of human calcium metabolism. J Bone Miner Res 3:489–495
Adams ND, Gray RW, Lemann J Jr (1979) The effects of oral CaCO3 loading and dietary calcium deprivation on plasma 1,25-dihydroxyvitamin D concentrations in healthy adults. J Clin Endocrinol Metab 48:1008–1016
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Guillemant, J., Guillemant, S. Comparison of the suppressive effect of two doses (500 mg vs 1500 mg) of oral calcium on parathyroid hormone secretion and on urinary cyclic AMP. Calcif Tissue Int 53, 304–306 (1993). https://doi.org/10.1007/BF01351833
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DOI: https://doi.org/10.1007/BF01351833