Abstract
Pancreatic secretions have been shown to be important in zinc absorption in experimental animals. Recently, complete surgical diversion of biliary and pancreatic secretions from the functioning small intestine has been utilized in Europe to treat morbid obesity. To determine the importance of pancreatic secretions in zinc absorption in the human, we measured hair and serum zinc levels in 14 patients having undergone complete biliopancreatic bypass 12–56 months earlier and compared these values with those obtained from 11 patients subjected to only partial biliopancreatic bypass as well as to six morbidly obese controls. No differences were observed in either hair or serum zinc levels between any of these groups of patients. Pancreatic secretions do not appear to be necessary for adequate zinc absorption in humans.
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Evans GW, Grace CI, Votava HJ: A proposed mechanism for zinc absorption in the rat. Am J Physiol 228:501–505, 1975
Weismann K, Roed-Petersen J, Hjorth N, Kopp H: Chronic zinc deficiency syndrome in a beer drinker with a billroth II resection. Int J Dermatol 15:757–761, 1976
Jacob RA, Sandstead HH, Solomons NW, Rieger C, Rothberg R: Zinc status and vitamin A transport in cystic fibrosis. Am J Clin Nutr 31:638–644, 1978
Scopinaro N, Gianetta E, Civalleri D, Bonalumni U, Friedman D, Bachi V: Partial and total biliopancreatic bypass in the surgical treatment of obesity. Int J Obesity 5:421–429, 1981
Antonson DL, Barak AJ, Vanderhoof JA: Determination of the site of zinc absorption in the rat small intestine. 109:142–147, 1979
Methfessel AH, Spencer H: Zinc metabolism in the rat. I. intestinal absorption of zinc. J Appl Physiol 34:58–62, 1973
Van Campen DR, Mitchell EA: Absorption of Cu64, Zn65, Mo99m, and Fe59 from ligated segments of the rat gastroin-testinal tract. J Nutr 86:120–124, 1965
Schwarz EJ, Kirchgessner M: Experimental studies on the absorption of zinc from different parts of the small intestine and various zinc compounds. Nutr Metab 18:157–166, 1975
Sahagian BM, Harding-Barlow I, Perry HM Jr: Uptakes of zinc, manganese, cadmium, and mercury by intact strips of rat intestine. J Nutr 90:259–267, 1966
Emes JH, Arthur D: The site of zinc absorption in the rat small intestine. Proc Soc Exp Biol Med 148:86–88, 1975
Pearson WN, Schwink T, Reich M:In vitro studies of zinc absorption in the rat.In Zinc Metabolism. AS Prasad (ed). Springfield, Illinois, Charles C Thomas, 1966, pp 239–249
Davies NT: Studies on the absorption of zinc by rat intestine. Br J Nutr 43:189–203, 1980
Sandstrom B, Arvidsson B, Cederblad A, Bjorn-Rasmussen E: Zinc absorption from composite meals. I. The significance of wheat extraction rate, zinc, calcium, and protein content in meals based on bread. Am J Clin Nutr 33:739–745, 1980
Evans GW, Johnson PE: Characterization and quantitation of a zinc-binding ligand in human milk. Pediatr Res 14:876–880, 1980
Halsted J, Smith J: Plasma zinc in health and disease. Lancet 1:332, 1970
Aggett PJ, Thorn JM, Delves HT, Harries JT, Clayton BE: Trace element malabsorption in exocrine pancreatic insufficiency. Monogr Paediatr 10:8–11, 1979
Boosalis MG, Evans GW, Mackie RD, McClain CJ: Impaired zinc absorption in pancreatic insufficiency. Clin Res 29:703A, 1981 (abstract)
Anonymous: On the entero-pancreatic circulation of endogenous zinc. Nutr Rev 39:162–163, 1981
Chase HP, Hambidge KM, Barnett SE, Houts-Jacobs MJ, Lenz K, Gillespie J: Low vitamin A and zinc concentrations in Mexican-American migrant children with growth retardation. Am J Clin Nutr 33:2346–2349, 1980
Buzina R, Jusic M, Sapunar J, Milanovic N: Zinc nutrition and taste acuity in school children with impaired growth. Am J Clin Nutr 33:2262–2267, 1980
Solomons NW: On the assessment of zinc and copper nutriture in man. Am J Clin Nutr 32:856–871, 1979
Danks DM: Diagnosis of trace metal deficiency with emphasis on copper and zinc. Am J Clin Nutr 34:278–280, 1981
Prasad AS, Rabbani P, Abbasii A, Bowersox E, Spivey-Fox MR: Experimental zinc deficiency in humans. Ann Intern Med 89:483–490, 1978
Faber J, Randolph JG, Robbins S, Smith JC: Zinc and copper status in young patients following jejunoileal bypass. J Surg Res 24:83–86, 1978
Atkinson RL, Dahms WT, Bray GA, Jacob R, Sandstead HH: Plasma zinc and copper in obesity and after intestinal bypass. Ann Intern Med 89:491–493, 1978
Meyer G: Intestinal bypass in zinc. Ann Intern Med 90:278, 1979 (letter to the editor)
Garofalo JA, Strong E, Good RA: Zinc deficiency and intestinal bypass procedures. Ann Intern Med 90:990, 1979 (letter to the editor)
Antonson DL, Vanderhoof JA: Zinc absorption following massive small bowel resection in the rat. Dig Dis Sci 27:789–793, 1982
Condon SC, Janes NJ, Wise L, Alpers DH: Role of caloric intake in the weight loss after jejunoileal bypass for obesity. Gastroenterology 74:34–37, 1978
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Vanderhoof, J.A., Scopinaro, N., Tuma, D.J. et al. Hair and plasma zinc levels following exclusion of biliopancreatic secretions from functioning gastrointestinal tract in humans. Digest Dis Sci 28, 300–305 (1983). https://doi.org/10.1007/BF01324945
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DOI: https://doi.org/10.1007/BF01324945