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Infection of rhesus monkeys and chimpanzees with Epstein-Barr virus

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Summary

Seventy-two nonhuman primates were entered into a long-term study to evaluate the pathogenicity of Epstein-Barr virus (EBV). Infectious virus was inoculated into 42 rhesus monkeys, 4 chimpanzees and 1 cynomolgus monkey. Immunostimulation or immunosuppression was attempted in 34 of these animals to enhance the oncogenic potential of the virus. Eleven inoculated animals were followed for more than 3 years and two were observed for 8 years. No tumors were observed in any of the animals; however, serological evaluation of the 47 inoculated primates and 25 matched controls indicated that at least 14 rhesus monkeys and the cynomolgus monkey were successfully infected with EBV. The potential use of rhesus monkeys as a model for EBV-induced disease in humans is discussed.

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Authors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    P. H. Levine & S. A. Leiseca

  2. Medical College of Pennsylvania and Hospital, Philadelphia, USA

    J. F. Hewetson

  3. Charles F. Pfizer, Inc., Maywood, New Jersey, USA

    K. A. Traul

  4. Litton Bionetics, Inc., Kensington, Maryland, USA

    A. P. Andrese, D. J. Granlund & Patricia Fabrizio

  5. Santa Clara Valley Medical Center, San Jose, California, USA

    D. A. Stevens

  6. Stanford University, Stanford, California, USA

    D. A. Stevens

Authors
  1. P. H. Levine
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  2. S. A. Leiseca
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  3. J. F. Hewetson
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  4. K. A. Traul
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  5. A. P. Andrese
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  6. D. J. Granlund
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  7. Patricia Fabrizio
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  8. D. A. Stevens
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With 2 Figures

Supported in part by Contracts NO 1-CP-4333 and NO 1-CP-61029 with the Carcinogenesis Extramural Program, Division of Cancer Cause and Prevention.

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Levine, P.H., Leiseca, S.A., Hewetson, J.F. et al. Infection of rhesus monkeys and chimpanzees with Epstein-Barr virus. Archives of Virology 66, 341–351 (1980). https://doi.org/10.1007/BF01320630

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  • DOI: https://doi.org/10.1007/BF01320630

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