Summary
The antiviral effect of interferon against encephalomyocarditis (EMC) virus infection in mice was enhanced by isoprinosine. However, the enhancement was only obtained when both interferon and the virus were inoculated into the peritoneum; the inoculation route of isoprinosine did not modify significantly the final results. In addition, the time sequence of injections was of great importance; generally the injection of isoprinosine had to precede that of interferon by a few hours.
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Chany, C., Cerutti, I. Enhancement of antiviral protection against encephalomyocarditis virus by a combination of isoprinosine and interferon. Archives of Virology 55, 225–231 (1977). https://doi.org/10.1007/BF01319908
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DOI: https://doi.org/10.1007/BF01319908