Abstract
Twenty selected patients with recurrent aphthous stomatitis in whom celiac disease had been specifically excluded were placed on a gluten-free diet. Five patients (25%) showed a favorable response to gluten withdrawal and a positive gluten challenge. Jejunal morphology was normal in all patients indicating gluten sensitivity without enteropathy. Gluten withdrawal provides a further method of treating some patients with recurrent aphthous stomatitis.
Similar content being viewed by others
References
Bateson MC, Hopwood D, MacGillivray JB: Jejunal morphology in multiple sclerosis. Lancet 1:1108–1110, 1979
Cook AW, Gupta JK, Pertschuk LP, Nidzgorski F: Multiple sclerosis and malabsorption. Lancet 1:1366, 1978
Crosby WH, Kugler HW: Intraluminal biopsy of the small intestine. Am J Dig Dis 2:236–241, 1957
Dahl R: Wheat sensitive—but not coeliac. Lancet 1:43–44, 1979
Dickerson JWT, Ballantyne L, Hastrop K: Food allergy. Lancet 1:773, 1978
Ellis A, Linaker BD: Non-coeliac gluten sensitivity. Lancet 1:1358–1359, 1978
Ferguson MM, Wray D, Carmichael HA, Russell RI, Lee FD: Coeliac disease associated with recurrent aphthae. Gut 21:223–226, 1980
Hutcheon AW, Wray D, Dagg JH, Ferguson MM, Mason DK, Lucie NP: Clinical and haematological screening in recurrent aphthae. Postgrad Med J 54:779–783, 1978
Lehner T: Autoimmunity in oral diseases, with special reference to recurrent oral ulceration. Proc R Soc Med 61:515–524, 1968
Lee FD: The intestinal mucosa in health and disease. MD thesis, 1970. University of Dundee.
Sircus W, Church R, Kelleher J: Recurrent aphthous ulceration of the mouth: A study of the natural history, aetiology and treatment. Q J Med 26:235–249, 1957
Walker DM, Rhodes J, Llewelyn J, Mead J, Dolby AE: Gluten hypersensitivity in recurrent aphthous ulceration. J Dent Res 58: (special issue C):1271, 1979
Wray D, Ferguson MM, Mason DK, Hutcheon AW, Dagg JH: Recurrent aphthae: Treatment with vitamin B12, folic acid, and iron. Br Med J 2:490–493, 1975
Wray D, Ferguson MM, Hutcheon AW, Dagg JH: Nutritional deficiencies in recurrent aphthae. J Oral Pathol 7:418–423, 1978
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wray, D. Gluten-sensitive recurrent aphthous stomatitis. Digest Dis Sci 26, 737–740 (1981). https://doi.org/10.1007/BF01316864
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01316864