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Ursodeoxycholic acid ingestion after ileal resection

Effect on biliary bile acid and lipid composition

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Abstract

The effect of ursodeoxycholic acid ingestion on biliary bile acids and biliary lipids was studied in six patients after ileal resection. All patients had bile acid malabsorption, as documented by increased breath and fecal excretion of14C after oral administration of [1-14C] cholylglycine. Fasting duodenal bile was collected by intubation before and seven days after ursodeoxycholic acid administration (4 g/day), and biliary bile acid and lipid composition were determined. Ursodeoxycholic acid ingestion increased the percentage of ursodeoxycholic acid in bile tenfold (3.6±2.6% vs 38.6±12.0%) and decreased chenodeoxycholic acid in bile by approximately 40%. Before ursodeoxycholic acid ingestion, bile was supersaturated in all patients. After ursodeoxycholic acid ingestion, cholesterol saturation decreased in all six patients by an average of 43%, and bile became unsaturated in five. Ursodeoxycholic acid ingestion had no effect on stool frequency. We conclude that, as in subjects with an intact enterohepatic circulation, ursodeoxycholic acid therapy has litholytic potential in patients after ileal resection.

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Authors and Affiliations

  1. Gastroenterology Unit, Division of Gastroenterology and Internal Medicine, Mayo Clinic and Mayo Foundation, 55901, Rochester, Minnesota

    Nicholas F. LaRusso MD & Johnson L. Thistle MD

Authors
  1. Nicholas F. LaRusso MD
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  2. Johnson L. Thistle MD
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Additional information

This work was supported by NIH Grants AM 15887 and RR 585 and by the Mayo Foundation. Part of this work was reported at the 1979 meeting of the American Gastroenterological Association and published in abstract form.

At the time this work was done, Dr. LaRusso was a Teaching and Research Scholar of the American College of Physicians.

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LaRusso, N.F., Thistle, J.L. Ursodeoxycholic acid ingestion after ileal resection. Digest Dis Sci 26, 705–709 (1981). https://doi.org/10.1007/BF01316859

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  • DOI: https://doi.org/10.1007/BF01316859

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