Skip to main content
SpringerLink
Log in

Interferon enhances T cell mediated cytotoxicity of H-2 compatible target cells infected with UV-inactivated herpes simplex virus

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Mouse L-cells infected with UV-inactivated HSV could serve as suitable targets for monitoring H-2 restricted cytotoxicity mediated by HSV-immune T cells. Cytotoxic potential of immune T cells for H-2 compatible targets exposed to UV-inactivated HSV was enhanced if the later were pretreated with mouse interferon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Doherty, P. C., Blanden, R. V., Zinkernagel, R. M.: Specificity of virusimmune effect or T cells for H-2K or H-2D compatible interactions: Implications for H-2 antigen diversity. Transplant. Rev.29, 89–124 (1976).

    Google Scholar 

  2. Gardner, I. D., Bowern, N. A., Blanden, R. V.: Cell mediated cytotoxicity against ectromelia virus infected target cells. III. Role of the H-2 gene complex. Europ. J. Immunol.5, 122–127 (1975).

    Google Scholar 

  3. Isaacs, A.: Interferon. Adv. Virus Res.10, 1–38 (1963).

    Google Scholar 

  4. Julius, M. H., Simpson, E., Herzenberg, L. A.: A rapid method for the isolation of functional thymus-derived murine lymphocytes. Europ. J. Immunol.3, 645–649 (1973).

    Google Scholar 

  5. Koszinowski, U., Ertl, H.: Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus. Nature (Lond.)255, 552–554 (1975).

    Google Scholar 

  6. Koszinowski, U., Gething, M. L., Waterfeld, M.: T-cell cytotoxicity in the absence of viral protein synthesis in target cells. Nature (Lond.)267, 160–163 (1977).

    Google Scholar 

  7. Lindahl, P., Leary, P., Gresser, I.: Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc. Nat. Acad. Sci.69, 721–725 (1972).

    Google Scholar 

  8. Lindahl, P., Leary, P., Gresser, I.: Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells. Proc. Nat. Acad. Sci.70, 2785–2788 (1973).

    Google Scholar 

  9. Miller, R. G., Dunkley, M.: Quantitative analysis of the51Cr release cytotoxicity assay for cytotoxic lymphocytes. Cell. Immunol.14, 284–302 (1974).

    Google Scholar 

  10. Pfizenmaier, K., Röllinghoff, M., Starzinski-Powitz, A., Falke, D., Wagner, H.: T-cell mediated cytotoxicity against herpes simplex virus-infected target cells. Nature (Lond.)265, 630–632 (1977).

    Google Scholar 

  11. Raff, M. C.: Role of thymus-derived lymphocytes in the secondary humoral immune response in mice. Nature (Lond.)226, 1257–1258 (1970).

    Google Scholar 

  12. Schrader, J. W., Edelman, G. M.: Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatibility complex. J. exp. Med.143, 523–539 (1977).

    Google Scholar 

  13. Sethi, K. K., Brandis, H.: Specifically immune mouse T-cells can destroy H-2 compatible murine target cells infected with herpes simplex virus types 1 or 2. Z. Immun. Forsch. (Immunobiology)153, 162–173 (1977).

    Google Scholar 

  14. Simpson, E., Gordon, R., Taylor, M., Martin, J., Chandler, P.: Micromethods for induction and assay of mouse mixed lymphocyte reactions and cytotoxicity. Europ. J. Immunol.5, 451–455 (1975).

    Google Scholar 

  15. Vignaux, F., Gresser, I.: Differential effects of interferon on the expression of H-2K, H-2D and Ia antigens on mouse lymphocytes. J. Immunol.118, 721–723 (1977).

    Google Scholar 

  16. Yap, K. L., Ada, G. L.: Cytotoxic T cells specific for influenza virus-infected target cells. Immunology32, 151–160 (1977).

    Google Scholar 

  17. Youngner, J. S., Scott, A. W., Hallum, J. V., Stinebring, W. R.: Interferon production by inactivated Newcastle disease virus in cell cultures and in mice. J. Bacteriol.92, 862–868 (1966).

    Google Scholar 

  18. Zinkernagel, R. M., Doherty, P. C.: Restriction ofin vitro T-cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogeneic system. Nature (Lond.)248, 701–702 (1974).

    Google Scholar 

  19. Zweerink, H. J., Courtneidge, S. A., Skehel, J. J., Crumpton, M. J., Askonas, B.: Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses. Nature (Lond.)267, 354–356 (1977).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Medizinische Mikrobiologie und Immunologie, Universität Bonn, Bonn-Venusberg, Federal Republic of Germany

    K. K. Sethi & H. Brandis

Authors
  1. K. K. Sethi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Brandis
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

With 1 Figure

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sethi, K.K., Brandis, H. Interferon enhances T cell mediated cytotoxicity of H-2 compatible target cells infected with UV-inactivated herpes simplex virus. Archives of Virology 57, 177–183 (1978). https://doi.org/10.1007/BF01315679

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01315679

Keywords

Search

Navigation