Skip to main content
Log in

Antigenic variation of Newcastle disease virus strains detected by monoclonal antibodies

  • Original Papers
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Forty Newcastle disease virus strains and isolates could be placed in eight distinct antigenic groups on their ability to induce binding of nine mouse monoclonal antibodies, raised against strain NDV-Ulster 2C, to infected MDBK cells as assessed by an indirect immuno-peroxidase test. Viruses placed in each group appeared to share both biological and epizootiological properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Alexander, D. J., Allan, W. H.: Newcastle disease virus pathotypes. Avian Path.3, 269–278 (1974).

    Google Scholar 

  2. Alexander, D. J., Collins, M. S.: The structural polypeptides of avian paramyxoviruses Archiv. Virology67, 309–323 (1981).

    Google Scholar 

  3. Alexander, D. J., Spackman, D., Allan, W. H., Borland, L.: Isolation of Newcastle disease virus from a wild mallard duck(Anas platyrhyncos). Vet. Rec.105, 328–329 (1979).

    Google Scholar 

  4. Allan, W. H., Lancaster, J. E., Toth, B.: Newcastle disease vaccines. Food and Agriculture Organization of the United Nations, Rome 1978.

    Google Scholar 

  5. Arias-Ibarrondo, J., Mikami, T., Yamamoto, H., Furuta, Y., Ishioka, S.: Studies on a paramyxovirus isolated from Japanes sparrow-hawks(Accipter virgatus gularis). Jap. J. Vet. Sci.40, 315–323 (1978).

    Google Scholar 

  6. Bankowski, R. A., Kinjo, J.: Tissue culture systems with Newcastle disease virus and relationship of antigenicity to immunogenicity among strains. Avian Dis.9, 157–170 (1965).

    Google Scholar 

  7. Birrer, M. J., Udem, S., Nathenson, S., Bloom, B. R.: Antigenic variants of measles virus. Nature293, 67–69 (1981).

    Google Scholar 

  8. Dawson, P. S., Allan, W. H.: The control of Newcastle disease by vaccination. Proc. 4th Europ. Poult. Conf. 591–598 (1973).

  9. Francis, D. W.: VVND has been in U.S. longer than realised. Poult. Digest36, 66–75 (1977).

    Google Scholar 

  10. Gerhard, W., Webster, R. G.: Selection and characterisation of antigenic variants of A/PR/8/32 (H1N1) influenza virus with monoclonal antibodies. J. exp. Med.148, 383–392 (1978).

    Google Scholar 

  11. Gomez-Lillo, M., Bankowski, R. A., Wiggins, A. D.: Antigenic relationships. among viscerotropic-velogenic and domestic strains of Newcastle disease virus Am. J. vet. Res.35, 471–475 (1974).

    Google Scholar 

  12. Granoff, A.: Studies on mixed infections with Newcastle disease virus. Virology9, 636–640 (1959).

    Google Scholar 

  13. Hannoun, C.: Isolation from birds of influenza viruses with human neuraminidase. Biol. Standard.39, 461–468 (1977).

    Google Scholar 

  14. Hannoun, C., Devaux, J. M.: Circulation enzootique permente de virus grippaux dans la baie de la Somme Comp. Immun. Microbiol. infect. Dis.3, 177–183 (1981).

    Google Scholar 

  15. Hanson, R. P.: Newcastle disease. In:Hofstad, M. S. (ed.), Diseases of Poultry, 6th ed. Ames, Iowa: Iowa State University Press 1972.

    Google Scholar 

  16. Kendal, A. P., Allan, W. H.: Comparative studies on Newcastle disease viruses. I. Virulence, antigenic specificity and growth kinetics. Microbios2, 273–284 (1970).

    Google Scholar 

  17. Komarov, A., Goldsmit, L.: Preliminary observation on the modification of a strain of Newcastle disease virus by intracerebral passage through ducklings. Vet. J.102, 212–218 (1946).

    Google Scholar 

  18. Lancaster, J. E.: Newcastle disease—a review of the geographical incidence and epizootiology. Wld. Poult. Sci. J.33, 155–165 (1977).

    Google Scholar 

  19. Lomniczi, B.: Thermostability of Newcastle disease virus strains of different virulence. Archiv. Virol.47, 249–255 (1975).

    Google Scholar 

  20. McFerran, J. B., Nelson, R.: Some properties of an avirulent Newcastle disease virus. Arch. ges. Virusforsch.34, 64–74 (1971).

    Google Scholar 

  21. Oxford, J.: The use of monoclonal antibodies in virology. J. Hyg. Camb.88, 361–368 (1982).

    Google Scholar 

  22. Pennington, T. H.: Antigenic differences between strains of Newcastle disease virus. Arch. Virol.56, 345–351 (1978).

    Google Scholar 

  23. Russell, P. H., Griffiths, P. C., Cannon, M. J.: A microwell immuno-peroxidase test for screening hybridomas and for diagnosing Newcastle disease virus and Sendai virus. J. Immunol. Meth. (in press).

  24. Russell, W. C., Patel, G., Precious, B., Sharp, I., Gardner, P. S.: Monoclonal antibodies against adenovirus type 5: preparation and preliminary classification. J. gen. Virol.56, 393–408 (1981).

    Google Scholar 

  25. Schloer, G.: Antigenic relationships among Newcastle disease virus mutants obtained from laboratory strains and from recent California isolates. Infect. Immun.10, 724–732 (1974).

    Google Scholar 

  26. Schloer, G., Spalatin, J., Hanson, R. P.: Newcastle disease virus antigens and strain variations. Am. J. vet. Res.36, 505–508 (1975).

    Google Scholar 

  27. Shortridge, K. F., Alexander, D. J.: Newcastle disease virus surveillance in Hong Kong on local and imported poultry. Res. vet. Sci.25, 204–206 (1978).

    Google Scholar 

  28. Simmons, G. C.: The isolation of Newcastle disease virus in Queensland. Aust. vet. J.43, 29–30 (1967).

    Google Scholar 

  29. Thorne, A. L. C., MacLeod, A. J.: The production and properties of Newcastle disease vaccine (Komarov strain) in Nigeria. Brit. vet. J.116, 427–435 (1960).

    Google Scholar 

  30. Walker, J. W., Heron, B. R., Mixson, M. A.: Exotic Newcastle disease eradication program in the United States. Avian Dis.17, 486–503 (1973).

    Google Scholar 

  31. Webster, R. G., Berton, M. T.: Analysis of antigenic drift in the haemagglutinin molecule of influenza B virus with monoclonal antibodies. J. gen. Virol.54, 243–251 (1981).

    Google Scholar 

  32. Webster, R. G., Kendal, A. P., Gerhard, W.: Analysis of antigenic drift in recently isolated influenza (H1N1) viruses using monoclonal antibody preparations. Virology96, 258–264 (1979).

    Google Scholar 

  33. Wiktor, T. J., Koprowski, H.: Antigenic variants of rabies virus. J. exp. Med.152, 99–112 (1980).

    Google Scholar 

  34. Yewdell, J. W., Gerhard, W.: Antigenic characterization of viruses by monoclonal antibodies. Ann. Rev. Microbiol.35, 185–206 (1981).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Russell, P.H., Alexander, D.J. Antigenic variation of Newcastle disease virus strains detected by monoclonal antibodies. Archives of Virology 75, 243–253 (1983). https://doi.org/10.1007/BF01314890

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01314890

Keywords

Navigation