Summary
The protective effects of the passive administration of convalescent serum from mice infected with Sendai virus were evaluated in mice challenged intranasally with wild-type and a pantropic variant (F1-R) of Sendai virus. Adoptive transfer of the serum efficiently prevented F1-R from infecting the systemic organs, but it failed to protect the mice from infections of the respiratory tracts by either virus. Virus replication in nasal turbinates was not diminished while infection in the lung was suppressed sufficiently for the infected mice to survive the infection. These findings suggest that serum antibody is less effective for the protection against viral infections on the surface of the respiratory tract, but it is effective for inhibition of spread of the virus into the systemic organs.
Similar content being viewed by others
References
Breider MA, Adams LG, Womack JE (1987) Influence of interferon in natural resistance of mice to Sendai virus pneumonia. Am J Vet Res 48: 1746–1750
Brownstein DG (1986) Sendai virus. In: Bhatt PN, Jacoby RO, Morse HC III, New AE (eds) Viral and mycoplasmal infections of laboratory rodents. Effects on biochemical research. Academic Press, New York, pp 37–61
Charlton D, Blandford G (1977) Immunoglobulin class-specific antibody response in serum, lungs, and broncholaveolar washings after primary and secondary Sendai virus infection in germfree mice. Infect Immun 17: 521–527
Clements ML, Betts RF, Tierney EL, Murphy BR (1986) Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus. J Clin Microbiol 24: 157–160
Degre M, Rollag Jr H (1980) Pathogenesis of Sendai virus infection in mice: on the possible role of interferon on the development of disease. Acta Pathol Microbiol Scand (B) 88: 177–181
Eaton GJ, Lerro A, Custer RP, Crane AR (1982) Eradication of Sendai virus pneumonitis from a conventional mouse colony. Lab Animal Sci 32: 384–386
Hocart MJ, Mackenzie JS, Stewart GA (1988) The IgG subclass responses induced by wild-type, cold-adapted and purified haemagglutinin from influenza virus A/Queensland/6/72 in CBA/CaH mice. J Gen Virol 69: 1873–1882
Homma M, Ohuchi M (1973) Trypsin action on the growth of Sendai virus in tissue culture cells. III. Structural differences of Sendai viruses grown in eggs and tissue culture cells. J Virol 12: 1457–1465
Iida T, Tajima M, Murata M (1973) Transmission of maternal antibodies to Sendai virus in mice and its significance in enzootic infection. J Gen Virol 18: 247–254
Itoh M, Shibuta H, Homma M (1987) Single amino acid substitution of Sendai virus at the cleavage site of the fusion protein confers trypsin resistance. J Gen Virol 68: 2939–2944
Iwai H, Machii K, Otsuka Y, Ueda K (1988) T cell subsets responsible for clearance of Sendai virus from infected mouse lungs. Microbiol Immunol 32: 305–315
Jones PD, Ada GL (1986) Influenza virus specific antibody-secreting cells in the murine lung during primary influenza infection. J Virol 60: 614–619
Kristensson K, Leestma J, Lundh B, Norrby E (1984) Sendai virus infection in the mouse brain: virus spread and long-term effects. Acta Neuropathol (Berl) 63: 89–95
Liew FY, Russell SM, Appleyard G, Brand CM, Beale J (1984) Cross protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity. Eur J Immunol 14: 350–356
Maru M, Sato K, Homma M (1987) Abstr 35th Gen Meet Soc Japan Virologists. Kyoto, p 4065
Mazanec MB, Nedrud JG, Lamm ME (1987) Immunoglobulin A monoclonal antibodies protect against Sendai virus. J Virol 61: 2624–2626
Nedrud JG, Liang X, Hague N, Lamm ME (1987) Combined oral/nasal immunization protects mice from Sendai virus infection. J Immunol 139: 3484–3492
Owens SL, Osebold JW, Zee YC (1981) Dynamics of B-lymphocytes in the lungs of mice exposed to aerosolized influenza virus. Infect Immun 33: 231–238
Parker JC, O'Beirne AJ, Collins Jr MJ (1979) Sensitivity of enzyme-linked immunosorbent assay, complement fixation, and hemagglutination inhibition antibody in laboratory mice. J Clin Microbiol 9: 444–447
Prince GA, Horswood RL, Camargo E, Koenig D, Chanock RM (1983) Mechanism of immunity to respiratory syncytial virus in cotton rats. Infect Immun 42: 81–87
Prince GA, Hemming VG, Horswood RL, Baron PA, Chanock RM (1987) Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats. J Virol 61: 1851–1854
Ramphal R, Cogliano RC, Shands Jr JW, Small Jr PA (1979) Serum antibody prevents lethal murine influenza pneumonitis but not tracheitis. Infect Immun 25: 992–997
Scheid A, Choppin PW (1974) Identification of biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity by proteolytic cleavage of an inactive precursor protein of Sendai virus. Virology 57: 475–490
Schulman JL, Khakpour M, Kilbourne ED (1968) Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice. J Virol 2: 778–786
Small Jr PA, Waldman RH, Bruno JC, Gifford GE (1976) Influenza infection in ferrets: role of serum antibody in protection and recovery. Infect Immun 13: 417–424
Smith CB, Purcell RH, Bellanti JA, Chanock RM (1966) Protective effect of antibody to parainfluenza type 1 virus. N Engl J Med 275: 1145–1152
Tashiro M, Homma M (1983) Pneumotropism of Sendai virus in relation to protease-mediated activation in mouse lungs. Infect Immun 39: 879–888
Tashiro M, Homma M (1983) Evidence of proteolytic activation of Sendai virus in mouse lung. Arch Virol 77: 127–137
Tashiro M, Homma M (1985) Protection of mice from wild-type Sendai virus infection by a trypsin-resistant mutant, TR-2. J Virol 53: 228–234
Tashiro M, Fujii Y, Nakamura K, Homma M (1988) Cell-mediated immunity induced in mice after vaccination with a protease activation mutant, TR-2, of Sendai virus. J Virol 62: 2490–2497
Tashiro M, Pritzer E, Khoshnan MA, Yamakawa M, Kuroda K, Klenk H-D, Rott R, Seto JT (1988) Characterization of a pantropic variant of Sendai virus derived from a host range mutant. Virology 165: 577–583
Taylor G, Stott EJ, Bew M, Fernie BF, Cote PJ, Collins AP, Hughes M, Jebbett J (1984) Monoclonal antibodies protect against respiratory syncytial virus infection in mice. Immunology 52: 137–142
Tsukui M, Ito H, Tada M, Nakata M, Miyajima H, Fujiwara K (1982) Protective effect of inactivated virus vaccine on Sendai virus infection in rats. Lab Anim Sci 32: 143–146
Virelizier JL (1975) Host defenses against influenza virus: the role of antihemagglutinin antibody. J Immunol 115: 434–439
Wagner DK, Clements ML, Reimer CB, Synder M, Nelson DL, Murphy BR (1987) Analysis of immunoglobulin G antibody responses after administration of live and inactivated influenza A vaccine indicates that nasal wash immunoglobulin G is a transduate from serum. J Clin Microbiol 25: 559–562
Walsh EE, Schlesinger JJ, Brandriss W (1984) Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies. Infect Immun 43: 756–758
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tashiro, M., Tobita, K., Seto, J.T. et al. Comparison of protective effects of serum antibody on respiratory and systemic infection of Sendai virus in mice. Archives of Virology 107, 85–96 (1989). https://doi.org/10.1007/BF01313881
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01313881