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Relationship of alcoholic hypertriglyceridemia to stage of liver disease and dietary lipid

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Abstract

To clarify contributions of alcoholic liver injury, dietary fat and acute ethanol intake to alcoholic hypertriglyceridemia, control subjects and alcoholics with fatty liver or cirrhosis were given a high fat meal with and without ethanol. The triglyceridemic response to the meal in patients with fatty liver (551.3±98.4 mgxhr/dl) was enhanced compared to controls (106.4±30.9) and characterized by increased fasting and postprandial pre-β lipoproteins. The cirrhotics' response (262.5±34.9) was characterized by minimal fasting and postprandial pre-β lipoproteins and increased postmeal chylomicrons. Ethanol added to the meal enhanced the lipemic response of controls, barely altered the response of patients with fatty liver, and decreased the response of cirrhotics. In an expanded group of alcoholic patients, the percentage of pre-β lipoproteins determined by electrophoresis reflected the degree of liver injury. Therefore, major determinants of alcoholic triglyceridemia are stage of liver injury and dietary lipid; electrophoretic determination of pre-β lipoproteins may indicate degree of alcoholic liver damage.

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Authors and Affiliations

  1. Alcoholism Research and Treatment Center, Bronx VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, New York

    Stephen A. Borowsky MD, William Perlow MD, Enrique Baraona MD &  Charles S. Lieber MD

  2. the Section of Liver Disease and Nutrition, Bronx VA Medical Center, New York, New York

    Stephen A. Borowsky MD, William Perlow MD, Enrique Baraona MD &  Charles S. Lieber MD

  3. the Mt. Sinai School of Medicine, New York, New York

    Stephen A. Borowsky MD, William Perlow MD, Enrique Baraona MD &  Charles S. Lieber MD

Authors
  1. Stephen A. Borowsky MD
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  2. William Perlow MD
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  3. Enrique Baraona MD
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  4. Charles S. Lieber MD
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Additional information

This study was supported in part by the Medical Research Service of the Veterans Administration, the National Council on Alcoholism, and USPHS grants AA-00224, AA03508, and AM-12511.

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Borowsky, S.A., Perlow, W., Baraona, E. et al. Relationship of alcoholic hypertriglyceridemia to stage of liver disease and dietary lipid. Digest Dis Sci 25, 22–27 (1980). https://doi.org/10.1007/BF01312728

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  • DOI: https://doi.org/10.1007/BF01312728

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