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In vitro isolation of a neutralization escape mutant of equine infectious anemia virus (EIAV)

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Summary

A neutralization escape mutant (A/1 E) of equine infectious anemia virus was isolated after 13 passages in cell culture in the presence of serum containing antibodies to type- and group-specific determinants of EIAV envelope glycoproteins. Loss of neutralization by the selecting serum correlated with loss of two epitopes in the major envelope glycoprotein gp90 of A/1 E which were present in a parallel variant isolated from a persistently infected pony.

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Authors and Affiliations

  1. Department of Veterinary Microbiology and Parasitology, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, U.S.A

    P. M. Rwambo, C. J. Issel & K. A. Hussain

  2. Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, U.S.A.

    C. J. Issel

  3. Department of Biochemistry, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, U.S.A.

    R. C. Montelaro

Authors
  1. P. M. Rwambo
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  2. C. J. Issel
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  3. K. A. Hussain
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  4. R. C. Montelaro
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Rwambo, P.M., Issel, C.J., Hussain, K.A. et al. In vitro isolation of a neutralization escape mutant of equine infectious anemia virus (EIAV). Archives of Virology 111, 275–280 (1990). https://doi.org/10.1007/BF01311062

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  • DOI: https://doi.org/10.1007/BF01311062

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