Summary
The complications of vaccination against small pox are discussed in relation to the contemplated use as vaccines of recombinant vaccinia viruses carrying the genes for “protective” antigens derived from a range of pathogens. Recombinant vaccines are potentially extremely valuable instruments in the fight against infectious diseases, but caution is needed in their deployment. In addition to the dangers associated with the pathogenicity of various strains of vaccinia virus, there may be problems related to the ecology of the poxviruses—especially orthopoxviruses. Before recombinant vaccinia virus vaccines are widely used, ecological research is urgently needed. It should cover not only the ecology of orthopoxviruses, but also possible interactions between engineered vaccinia viruses released into the environment and wild viruses which may be resident in both target and non-target species in a wide selection of habitats.
References
Baxby D (1981) Jenner's smallpox vaccine. The riddle of vaccinia virus and its origin. Heinemann, London
Baxby D, Gaskell RM, Gaskell CJ, Bennett M (1986) Ecology of orthopoxviruses and use of recombinant vaccinia vaccines. Lancet ii: 850–851
Bedson HS, Dumbell KR (1964) Hybrids derived from the viruses of alastrim and rabbit pox. J Hyg (Camb) 62: 141–146
Buller RWL, Smith GL, Cremer K, Notkins AL, Moss B (1985) Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinasenegative phenotype. Nature 317: 813–815
Buller RWL, Chakrabarty S, Cooper JA, Twardzik DR, Moss B (1988) Deletion of the vaccinia virus growth factor gene reduces virus virulence. J Virol 62: 866–874
Chandra R, Garg SK, Yadav M (1985) Characteristics of virus isolates from cases of pox in buffaloes. Indian J Vet Med 5: 101–106
Collier LH (1955) The development of a stable smallpox vaccine. J Hyg (Camb) 55: 76–101
Conybeare ET (1964) Illness attributed to smallpox vaccination during 1951–1960. Monthly Bull Min Health Public Health Lab Serv 23: 126–133
Conybeare ET (1964) Illnesses attributed to smallpox vaccination 1951–1960. Part II—Illnesses reported as affecting the central nervous system. Monthly Bull Min Health Public Health Lab Serv 23: 150–159
Donnally HH (1939) Revaccination after two to three years in children primarily vaccinated with culture vaccine (Rivers) compared with those primarily vaccinated with calf lymph virus. JAMA 113: 1796–1800
Donnally HH, Nicholson MM, Anderson WS, Grosvenor MH (1940) Smallpox vaccination of newborn infants with culture virus and with calf lymph virus. Am J Dis Child 59: 322–331
Dumbell KR (1985) Aspects of the biology of orthopoxviruses relevant to the use of recombinant vaccinias as field vaccines. In: Quinnan GV (ed) Vaccinia viruses as vectors for vaccine antigens. Elsevier, New York, pp 9–13
Dumbell KR, Bedson HS (1964) The use of ceiling temperature and reactivation in the isolation of pox virus hybrids. J Hyg (Camb) 62: 133–140
Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID (1988) Smallpox and its eradication. World Health Organization, Geneva
Flexner C, Hügin A, Moss B (1987) Prevention of vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression. Nature 330: 259–262
Gershon PD, Kitching RP, Hammond JM, Black DN (1989) Poxvirus genetic recombination during natural virus transmission. J Gen Virol 70: 485–489
Halsey NA, Henderson DA (1987) HIV infection and immunization against other agents. N Engl J Med 316: 683–685
Herrlich A, Mayr A, Mahnel H, Muntz E (1963) Experimental studies on transformation of the variola virus into the vaccinia virus. Arch Ges Virusforsch 12: 579–599
Hurst EW (1953) The post-infection encephaliti. Br Med Bull 9: 234–236
Jenner E (1798) An enquiry into the causes and effects of the variolae vaccinae, a disease discovered in some of the western counties in England, particularly Gloucestershire, and known by the name of the cow pox. Sampson Low, London
Jones L, Ristow S, Yilma T, Moss B (1986) Accidental human vaccination with vaccinia virus expressing nucleoprotein gene. Nature 319: 543
Kaplan C (1960) Titration of vaccinia virus by intravenous injection of chick embryos. Bull WHO 22: 393–397
Kaplan C, Healing TD, Evans N, Healing L, Prior A (1980) Evidence of infection by viruses in small British field rodents. J Hyg (Camb) 84: 285–294
Kieny MP, Lathe R, Drillien R, Spehner D, Skory S, Schmitt D, Wiktor T, Koprowski H, Lecocq JP (1984) Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature 312: 163–166
Koprowski H, Celis E, Curtis P, Dietzschold B, Rupprecht C, Tollis M, Wunner W (1987) Rabies experiment. Nature 326: 636
Ladnyi ID, Ziegler P, Kima A (1972) Human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bull WHO 46: 593–597
Lane JM, Ruben FL, Neff JM, Millar JD (1969) Complications of smallpox vaccination, 1968. National surveillance in the United States. N Engl J Med 281: 1201–1208
Lourie B, Bingham PC, Evans HH, Foster SO, Nakano JH, Herrmann KL (1972) Human infection with monkeypox virus: laboratory investigation of six cases in West Africa. Bull WHO 46: 633–639
Lourie B, Nakano JH, Kemp GE, Setzer HW (1975) Isolation of poxvirus from an African rodent. J Infect Dis 132: 677–681
Moss B, Smith GL, Gerin JL, Purcell RH (1984) Live recombinant vaccinia virus protects chimpanzees against hepatitis B. Nature 311: 67–69
Palca J (1986) Genetic manipulation. Living outside regulation. Nature 324: 20
Palca J (1986) Rabies vaccine. Enquiry into Argentine trials. Nature 324: 609
Palca J (1988) Row over vaccine trial. Nature 331: 470
Panicali D, Davis SW, Weinberg RL, Paoletti E (1983) Construction of live vaccines using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus haemagglutinin. Proc Natl Acad Sci USA 80: 5364–5368
Polak MF (1973) Complications of smallpox vaccination in the Netherlands, 1959–1970. In: Regamey RH, Cohen H (eds) International symposium on smallpox vaccine, Bilthoven, 1972. Karger, Basel, pp 235–254 (Symposia series in immunobiological standardization, vol 19)
Polak MF, Beunders BJW, van der Werf A, Sanders EW, van Klaveren JN, Brans LM (1963) A comparative study of clinical reactions observed after application of several smallpox vaccines in primary vaccination of young adults. Bull WHO 29: 311–322
Redfield RR, Wright DC, James WD, Jones TS, Brown C, Burke DS (1987) Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease. N Engl J Med 316: 673–676
Rivers TM (1931) Cultivation of vaccinia virus for Jennerian prophylaxis in man. J Exp Med 54: 453–461
Rivers TM, Ward SM (1933) Further observations on the cultivation of vaccine virus for Jennerian prophylaxis in man. J Exp Med 58: 635–648
Rivers TM, Ward SM, Baird RD (1939) Amount and duration of immunity induced by intradermal inoculation of cultured vaccine virus. J Exp Med 69: 857–866
Smith GL, Mackett M, Moss B (1983) Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen. Nature 302: 490–495
Smith GL, Murphy BR, Moss B (1983) Construction and characterization of an infectious vaccinia virus that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters. Proc Natl Acad Sci USA 80: 7155–7159
Strayer DS, Skaletsky E, Cabirac GF, Sharp PA, Corbeil LB, Leibowitz JL (1983) Malignant rabbit fibroma causes immunosuppression in rabbits. J Immunol 130: 399–404
Strayer DS, Sell S (1983) Immunohistology of malignant rabbit fibroma virus—a comparative study with rabbit myxoma virus. J Natl Cancer Inst 71: 105–116
Turnbull HM, McIntosh J (1926) Encephalomyelitis following vaccination. Br J Exp Pathol 7: 181–222
Upton C, McFadden G (1986) Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus. Virology 152: 308–321
Vries E de (1960) Postvaccinial perivenous encephalitis. Elsevier, Amsterdam
Waddington E, Bray PT, Evans AD, Richards IDG (1964) Cutaneous complications of mass vaccination in South Wales 1962. Trans St John's Hosp Dermatol Soc 50: 22–42
Weber G, Lange J (1961) Zur Variationsbreite der “Inkubationszeiten” postvakzinaler zerebraler Erkrankungen. Dtsch Med Wochenschr 86: 1461–1468
Williams RT, Dunsmore JD, Parer I (1972) Evidence for the existence of latent myxoma virus in rabbits [Oryctolagus cuniculi (L.)]. Nature 238: 99–101
Wilson G (1967) The hazards of immunization. The Athlone Press, London
Zagury D, Bernard J, Leonard R, Cheynier R, Feldman M, Sarin PS, Gallo RC (1986) Long-term culture of HTLV-III-infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science 231: 850–853
Zagury D, Leonard R, Fouchard M, Reveil B, Bernard J, Itelle D, Catlan A, Zirimwabagangabo L, Kalumba M, Justin W, Salaun J, Goussard B (1987) Immunization against AIDS in humans. Nature 326: 249–250
Zagury D, Bernard J, Cheynier R, Leonard R, Fouchard M, Reveil B, Itelle D, Zirimwabagangabo L, Mbayo K, Justin W, Salaun J, Goussard B, Dechazal L, Burny A, Nara P, Gallo RC (1988) A group specific anamnestic immune reaction against HIV-1 induced by a candidate vaccine against AIDS. Nature 332: 728–731
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Kaplan, C. Vaccinia virus: a suitable vehicle for recombinant vaccines?. Archives of Virology 106, 127–139 (1989). https://doi.org/10.1007/BF01311044
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DOI: https://doi.org/10.1007/BF01311044