Summary
RNA and DNA fractions prepared from nucleic acids obtained from normal and scrapie-infected hamster brains following exhaustive treatment with nuclease were used as probes in a search for a specific scrapie nucleic acid. Employing RNA blot hybridization a 2.3 Kb RNA was detected in higher concentration in scrapie-infected hamster brains than in normal controls. Our data suggests that scrapie disease may be associated with the differential expression of a series of host genes.
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Borrás, T., Merendino, J.J. & Gibbs, C.J. Molecular hybridization studies with scrapie brain nucleic acids. Archives of Virology 88, 79–90 (1986). https://doi.org/10.1007/BF01310892
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DOI: https://doi.org/10.1007/BF01310892