Skip to main content
Log in

Rabies virus in the tonsils of a carrier dog

  • Original Papers
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

A female dog, inoculated with a rabies isolate from the saliva of an apparently healthy Ethiopian dog, developed rabies but later recovered without supportive treatment. Rabies virus was isolated from the saliva collected 42, 169 and 305 days after recovery. Sixteen months after it recovered, the dog suddenly died after giving birth to two stillborn puppies. At necropsy, viral antigen could be detected in the tonsils and the brain tissue, but viable virus was isolated from the Palatine tonsils only.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Baer, G. M., Shantha, T. R., Bourne, G. H.: The pathogenesis of street rabies virus in rats. Bull. W.H.O.38, 119–125 (1968).

    Google Scholar 

  2. Bell, J. F.: Latency and abortive rabies. In:Baer, G. M. (ed.), The Natural History of Rabies, Vol. I, 331–354. New York: Academic Press 1975.

    Google Scholar 

  3. Charlton, K. M., Casey, G. A.: Experimental rabies in skunks. Immunofluorescence light and electron microscopic studies. Lab. Invest.41, 36–44 (1979).

    Google Scholar 

  4. Dean, D. J., Evans, W. M., McClure, R. C.: Pathogenesis of rabies. Bull. W.H.O.29, 803–811 (1963).

    Google Scholar 

  5. Diaz, A. M. O., Fuenzalida, E., Bell, J. F.: Nonfatal rabies in dogs and cats. Ann. Microbiol. (Paris)126, 503–509 (1975).

    Google Scholar 

  6. Erlandson, R. A.: A new Maraglas D.E.R. (R) 732 embedment for electron microscopy. J. Cell Biol.22, 704–709 (1964).

    Google Scholar 

  7. Fekadu, M.: Atypical rabies in dogs in Ethiopia (Background document No. 44, Geneva, 11–17 June 1969), as quoted by Bell JF. In:Baer, G. M. (ed.), The Natural History of Rabies, Vol. I, 348. New York: Academic Press 1975.

    Google Scholar 

  8. Fekadu, M.: Atypical rabies in dogs in Ethiopia. Ethiopian Med. J.10, 79–86 (1972).

    Google Scholar 

  9. Fekadu, M.: Asymptomatic non-fatal canine rabies. LancetI, 569 (1975).

    Google Scholar 

  10. Fekadu, M., Baer, G. M.: Recovery from clinical rabies of 2 dogs inoculated with a rabies virus strain from Ethiopia. Am. J. Vet. Res.41, 1632–1634 (1980).

    Google Scholar 

  11. Fekadu, M., Chandler, F. W., Harrison, A. K.: Pathogenesis of rabies in dogs inoculated with an Ethiopian rabies virus strain. Immunofluorescence, histologic and ultrastructural studies of the central nervous system. Arch. Virol.71, 109–126 (1982).

    Google Scholar 

  12. Fekadu, M., Shaddock, J. H., Baer, G. M.: Intermittent excretion of rabies virus in the saliva of a dog two and six months after it had recovered from experimental rabies. Am. J. Trop. Med. Hyg.30, 1113–1115 (1981).

    Google Scholar 

  13. Fischman, H. R., Strandberg, J. D.: Inapparent rabies virus infection of the central nervous system. J. Am. Vet. Med. Assoc.163, 1050–1055 (1973).

    Google Scholar 

  14. Goldwasser, R. A., Kissling, R. E.: Fluorescent antibody staining of street and fixed rabies virus antigen. Proc. Soc. Exp. Biol. Med.98, 219–223 (1958).

    Google Scholar 

  15. Granoff, A.: The interaction of Newcastle disease virus and neutralizing antibody. Virology25, 38–47 (1965).

    Google Scholar 

  16. Hattwick, M. A. W., Weis, T. T., Stechschulte, C. J., Baer, G. M., Gregg, M. B.: Recovery from rabies. A case report. Ann. Intern. Med.76, 931–942 (1972).

    Google Scholar 

  17. Kahn, D. E., Gillespie, J. H.: Feline virus: Pathogenesis of picornavirus infection in cat. Am. J. Vet. Res.32, 521–531 (1971).

    Google Scholar 

  18. Koprowski, H.: The mouse inoculation test. In:Kaplan, M. M., Koprowski, H. (eds.), Laboratory Techniques in Rabies, 3rd ed., 85–93. Geneva: World Health Organization 1973.

    Google Scholar 

  19. Lodmell, D. L., Bell, J. F., Moore, G. J., Raymond, G. H.: Comparative study of abortive and nonabortive rabies in mice. J. Infect. Dis.119, 569–580 (1969).

    Google Scholar 

  20. Lynn, J. A., Martin, J. H., Race, G. J.: Recent improvements of histologic techniques for the combined light and electron microscopic examination of surgical specimens. Am. J. Clin. Pathol.45, 704–713 (1966).

    Google Scholar 

  21. Murphy, F. A., Bauer, S. P.: Early street rabies virus infection in striated muscle and later progression to the central nervous system. Intervirology3, 256–268 (1974).

    Google Scholar 

  22. Murphy, F. A., Bauer, S. P., Harrison, A. K., Winn, W. C.: Comparative pathogenesis of rabies and rabies-like viruses. Viral infection and transit from inoculation site to the central nervous system. Lab. Invest.28, 361–376 (1973).

    Google Scholar 

  23. Murphy, F. A., Bell, J. F., Bauer, S. P., Gardner, J. J., Moore, G. J., Harrison, A. K., Coe, J. E.: Experimental chronic rabies in the cat. Lab. Invest.43, 231–241 (1980).

    Google Scholar 

  24. Murphy, F. A., Harrison, A. K., Winn, W. C., Bauer, S. P.: Comparative pathogenesis of rabies and rabies-like viruses. Infection of the central nervous system and centrifugal spread of virus to peripheral tissues. Lab. Invest.29, 1–16 (1973).

    Google Scholar 

  25. Perl, D. P., Bell, J. F., Moore, G. J., Stewart, S. J.: Chronic recrudescent rabies in a cat. Proc. Soc. Exp. Biol. Med.155, 540–548 (1977).

    Google Scholar 

  26. Porras, C., Jose Barbosa, J., Fuenzalida, E., Adaros, H. L., Oviedo de Diaz, A. M., Furst, J.: Recovery from rabies in man. Ann. Intern. Med.85, 44–48 (1976).

    Google Scholar 

  27. Povey, R. C., Wardly, R. C., Jessen, H.: Feline picornavirus infection: Thein vivo carrier state. Vet. Rec.92, 224–229 (1973).

    Google Scholar 

  28. Veeraraghavan, N.: Studies on the salivary excretion of rabies virus by the dog from Surandi. In: Pasteur Institute Annual Report of the Director, 1968, and Scientific Report, 1969. Madras: Pasteur Institute 1970.

  29. Venable, J. H., Coggeshall, R.: A simplified lead acetate stain for use in electron microscopy. J. Cell Biol.25, 407–413 (1965).

    Google Scholar 

  30. Veterinary Record: Tonsils in the pathogenesis of disease. Vet. Rec.95, 234 (1974).

    Google Scholar 

  31. Vetri, R. W., Sprinkle, P. M., McClung, J. E.: Epstein-Barr virus associated with episodes of recurrent tonsillitis. Arch. Otolaryngol.101, 552–556 (1975).

    Google Scholar 

  32. Wardley, R. C., Povey, R. C.: The pathology and site of persistence associated with three strains of feline calicivirus. Res. Vet. Sci.23, 15–19 (1977).

    Google Scholar 

  33. Wiktor, T. J., Clark, H. F.: Application of the plaque assay technique to the study of rabies-neutralizing antibody interaction. Ann. Microbiol. (Inst. Pasteur)124, 271–282 (1973).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

With 4 Figures

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fekadu, M., Shaddock, J.H., Chandler, F.W. et al. Rabies virus in the tonsils of a carrier dog. Archives of Virology 78, 37–47 (1983). https://doi.org/10.1007/BF01310857

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01310857

Keywords

Navigation