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Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins

Is the nicotinic acetylcholine receptor an HIV receptor?

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Summary

We have found a striking homology between the sequence 164–174 of HIV-1 gp120 and the sequence 30–40 of snake venom neurotoxins; this sequence homology is very similar to that existing between the same region of snake venom neurotoxins and rabies virus glycoprotein.

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References

  1. Bracci L, Antoni G, Cusi MG, Lozzi L, Niccolai N, Petreni S, Rustici M, Santucci A, Soldani P, Valensin PE, Neri P (1988) Antipeptide monoclonal antibodies inhibit the binding of rabies virus glycoprotein and alpha-bungaratoxin to the nicotinic acetylcholine receptor. Mol Immunol 25: 881–888

    Google Scholar 

  2. Burrage TG, Tignor GH, Smith AL (1985) Rabies virus binding at neuromuscular junctions. Virus Res 2: 273–289

    Google Scholar 

  3. Clapham PR, Weber JN, Whitby D, McIntosh K, Dalgleish AG, Maddon PJ, Deen KC, Sweet RW, Weiss RA (1989) Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells. Nature 337: 368–370

    Google Scholar 

  4. Dufton MJ, Hider RC (1983) Conformational properties of the neurotoxins and cytotoxins isolated from elapid snake venoms. CRC Crit Rev Biochem 14: 113–171

    Google Scholar 

  5. Endo T, Tamiya N (1987) Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms. Pharmacol Ther 34: 403–451

    Google Scholar 

  6. Goldman D, Deneris E, Luyten W, Kochhar A, Patrick J, Heinemann S (1987) Members of the nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system. Cell 48: 965–973

    Google Scholar 

  7. Grant GA, Chiappinelli VA (1985) k-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe. Biochemistry 24: 1532–1537

    Google Scholar 

  8. Harouse JM, Kunsch C, Hartle HT, Laughlin MA, Hoxie JA, Wigdahl B, Gonzales-Scarano F (1989) CD4-independent infection of human neural cells by human immunodeficiency virus type 1. J Virol 63: 2527–2533

    Google Scholar 

  9. Ho DD, Rota TR, Shooley RT (1985) Isolation of HTLV III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 313: 1493–1497

    Google Scholar 

  10. Ho DD, Pomerantz RJ, Kaplam JC (1987) Pathogenesis of infection with human immunodeficiency virus. N Engl J Med 317: 278–286

    Google Scholar 

  11. Lentz TL, Burrage TG, Smith AL, Crick J, Tignor GH (1982) Is the acetylcholine receptor a rabies virus receptor? Science 215: 182–184

    Google Scholar 

  12. Lentz TL, Wilson PT, Hawrot E, Speicher DW (1984) Amino acid sequence similarity between rabies virus glycoprotein and snake venom curaremimetic neurotoxins. Science 226: 847–848

    Google Scholar 

  13. Levy JA, Shimabukuro J, Hollander H, Mills J, Kaminsky L (1985) Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet 2: 586–588

    Google Scholar 

  14. Navia BA, Cho E-S, Petito CK, Price RW (1986) The AIDS dementia complex, II: neuropathology. Ann Neurol 23: 38–48

    Google Scholar 

  15. Rustici M, Santucci A, Lozzi L, Petreni S, Spreafico A, Neri A, Bracci L, Soldani P (1989) A monoclonal antibody to a synthetic fragment of rabies virus glycoprotein binds ligands of the nicotinic cholinergic receptor. J Mol Rec 2: 51–55

    Google Scholar 

  16. Schoepfer R, Luther M, Lindstrom J (1988) The human medulloblastoma cell line TE671 expresses a muscle-like acetylcholine receptor. FEBS Lett 226: 235–240

    Google Scholar 

  17. Schwartz RM, Dayhoff MO (1978) Atlas of protein sequence and structure, vol 5, suppl 3. National Biomedical Research Foundation, Washington, DC

    Google Scholar 

  18. Wain-Hobson S, Sonigo P, Danos O, Cole S, Alizon M (1985) Nucleotide sequence of the AIDS virus, LAV. Cell 40: 9–17

    Google Scholar 

  19. Weber J, Clapham P, McKeating J, Stratton M, Robey E, Weiss R (1989) Infection of brain cells by diverse Human Immunodeficiency Virus isolates: role of CD4 receptor. J Gen Virol 70: 2653–2660

    Google Scholar 

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Authors and Affiliations

  1. Dipartimento di Chimica, Sezione di Chimica Medica, Universitá di Siena, Siena, Italy

    P. Neri, Luisa Bracci, M. Rustici & Annalisa Santucci

Authors
  1. P. Neri
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  2. Luisa Bracci
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  3. M. Rustici
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  4. Annalisa Santucci
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Neri, P., Bracci, L., Rustici, M. et al. Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins. Archives of Virology 114, 265–269 (1990). https://doi.org/10.1007/BF01310756

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  • DOI: https://doi.org/10.1007/BF01310756

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