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Feline herpesvirus type 1 glycoproteins eliciting virus neutralizing and hemagglutination-inhibiting antibodies

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Summary

Monoclonal antibodies (MoAbs) to feline herpesvirus type 1 (FHV-1) were produced to identify the virus-specified immunogenic proteins. When antigens recognized by the MoAbs were investigated by immunoblot and immunoprecipitation assays using FHV-1-infected cell lysate, four groups of immunogenic proteins were identified. MoAbs directed against 60 kDa, 113 kDa, and 143 kDa/108 kDa glycoproteins had virus neutralizing activities, but those against 170 kDa protein did not. Furthermore, MoAbs to the 60 kDa glycoprotein also showed hemagglutination-inhibition activity, indicating that this glycoprotein might be the hemagglutinin.

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Authors and Affiliations

  1. Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

    T. Horimoto, J. A. Limcumpao, Y. Tohya, E. Takahashi & T. Mikami

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  1. T. Horimoto
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  2. J. A. Limcumpao
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  3. Y. Tohya
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  4. E. Takahashi
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  5. T. Mikami
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Horimoto, T., Limcumpao, J.A., Tohya, Y. et al. Feline herpesvirus type 1 glycoproteins eliciting virus neutralizing and hemagglutination-inhibiting antibodies. Archives of Virology 111, 127–132 (1990). https://doi.org/10.1007/BF01310510

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  • DOI: https://doi.org/10.1007/BF01310510

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