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Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus

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Summary

The mechanism of cell death induced by feline immunodeficiency virus (FIV) infection was investigated in an interleukin 2(IL-2)-dependent T-lymphoblastoid cell line (MYA-1). DNA extracted from FIV-infected MYA-1 cells showed a ladder of nucleosomal DNA, indicating that the cytopathic effect (CPE) observed in these cells was due to apoptosis. Infection of MYA-1 cells with FIV was associated with suppression of the proliferative response of the cells to exogenous IL-2 prior to DNA fragmentation. These findings suggest that FIV-induced CPE in these T-lymhoblastoid cells is associated with apoptosis possibly due to a defect in the IL-2 signal transduction pathway.

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Authors and Affiliations

  1. Department of Veterinary Internal Medicine, Faculty of Agriculture, The University of Tokyo, Tokyo, Japan

    K. Ohno, Y. Okamoto, T. Watari, R. Goitsuka, H. Tsujimoto & A. Hasegawa

  2. Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Tokyo, Japan

    T. Miyazawa & T. Mikami

Authors
  1. K. Ohno
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  2. Y. Okamoto
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  3. T. Miyazawa
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  4. T. Mikami
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  5. T. Watari
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  6. R. Goitsuka
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  7. H. Tsujimoto
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  8. A. Hasegawa
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Ohno, K., Okamoto, Y., Miyazawa, T. et al. Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus. Archives of Virology 135, 153–158 (1994). https://doi.org/10.1007/BF01309772

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  • DOI: https://doi.org/10.1007/BF01309772

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