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Prostaglandins and chemotherapy-induced ulcers in dogs

  • Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog
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Abstract

About 50% of patients receiving intrahepatic infusion of 5-fluorouracil deoxyriboside (5-FUDR) for colorectal cancer with hepatic metastasis develop significant gastroduodenal lesions. This paper reviews two studies on the effect of 16,16 dimethyl prostaglandin E2 (DMPGE2) on 5-fluorouracil-induced mucosal lesions in dogs. DMPGE2 at high doses (2 μg·kg−1·h−1), which reduced histamine-stimulated gastric acid secretion by 65%, reduced gastric mucosal injury. Interestingly, DMPGE2 at much lower doses (0.02 μg·kg−1·h−1), which had no effect on histamine-stimulated gastric acid secretion, was also effective in lowering gastric mucosal injury. These animal studies, if supported by the results of a larger patient study, would provide a rational basis for the use of prostaglandins in the prophylaxis and treatment of chemotherapy-induced ulcers.

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References

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Authors and Affiliations

  1. Digestive Diseases Research Center, Division of Gastroenterology, King-Drew Medical Center and UCLA School of Medicine, Los Angeles, California

    P. Bright-Asare MD (Chief), I. Giannikopoulos MD & J. T. Whiten PhD

Authors
  1. P. Bright-Asare MD
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  2. I. Giannikopoulos MD
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  3. J. T. Whiten PhD
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Additional information

This study was supported by a grant from the Hektoen Institute, Chicago, Ill., and in part by NIADDK grant (AM 17328, AM 27463) and by a grant from Glaxo, Inc. and Los Angeles Brotherhood Crusade.

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Bright-Asare, P., Giannikopoulos, I. & Whiten, J.T. Prostaglandins and chemotherapy-induced ulcers in dogs. Digest Dis Sci 30 (Suppl 11), 201S–203S (1985). https://doi.org/10.1007/BF01309409

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  • DOI: https://doi.org/10.1007/BF01309409

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