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Liver function in physically trained subjects

Galactose elimination capacity, plasma disappearance of indocyanine green, and aminopyrine metabolism in long-distance runners

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Abstract

Physical exercise and physical training are known to affect several aspects of hepatic metabolism. To assess whether adaptation to long-lasting exercise modifies microsomal drug metabolism, 8 long-distance runners were compared with a group of medical students having significantly lower maximal rates of oxygen consumption. At rest the hepatic galactose elimination capacity and the indocyanine green plasma disappearance rate used as reference methods were the same in both groups. The plasma clearance of ([14C]dimethylamine) aminopyrine and the kinetics of14CO2 in breath did not differ either. It is concluded that adaptation to long-lasting exercise can occur without evidence for changes in hepatic galactokinase activity, liver blood flow, or microsomal metabolism of aminopyrine.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH-3010, Berne, Switzerland

    J. J. Ducry MD, H. Howald MD, T. Zysset PhD &  J. Bircher MD

  2. Research Institute of the Swiss School for Physical Education and Sports, Magglingen, Switzerland

    J. J. Ducry MD, H. Howald MD, T. Zysset PhD &  J. Bircher MD

Authors
  1. J. J. Ducry MD
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  2. H. Howald MD
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  3. T. Zysset PhD
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  4. J. Bircher MD
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Supported by the Swiss National Science Foundation.

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Ducry, J.J., Howald, H., Zysset, T. et al. Liver function in physically trained subjects. Digest Dis Sci 24, 192–196 (1979). https://doi.org/10.1007/BF01308428

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