Abstract
The relationship between duodenitis and the outcome of duodenal ulcers was propectively investigated by evaluating the frequency and extent of bulbar duodenitis before and after short-term medical treatment of the ulcer. Duodenitis appeared to be more frequent and more severe in the bulbar area close to the ulcer and was more widespread in the bulb of patients whose ulcer did not respond to treatment. After medical treatment, duodenitis improved only in the ulcer area and only in patients with complete ulcer healing. While confirming that, in some patients, duodenitis may well be an inflammatory reaction to the presence of the ulcer, data from the present study indicate that, in other patients, duodenitis, throughout the bulb, does not seem to be influenced by the outcome of the ulcer or the treatment. These findings suggest that there are subpopulations of duodenal ulcer patients who differ according to the pattern of bulbar duodenitis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cheli R: Duodenitis and duodenal ulcer. A biopsy study. Digestion 1:175–182, 1968
Tweedle DEF, Ravenscroft MM: Duodenitis. Gut 20:A434, 1979
Thomson WO, Joffe SN, Robertson AG, Lee FD, Imrie CW, Blumgart LH: Is duodenitis a dyspeptic myth? Lancet 2:1197–1198, 1977
Joffe SN, Lee FD, Blumgart LH: Duodenitis. Clin Gastroenterol 7:635–650, 1978
Stephan JG, Lesna M, Venables CW: Endoscopic appearances and histological changes in ulcer-associated duodenitis. Br J Surg 65:438–441, 1978
Gilmour HM, Forrest JAH, Fettes M, Logan RFA, Heading RC: The effect of cimetidine on duodenitis.In Cimetidine. C Mastell, F Lance (eds). The Westminster Hospital Symposium. Edinburgh, Churchill Livingstone, 1978, pp 141–146
Kreuning J: Chronic non-specific duodenitis. A clinical and histopathological study. Thesis, Delft, W.D. Meinema B.V., 1978
Paoluzi P, Pallone F, Palazzesi P, Marcheggiano A, Iannoni C: Frequency and extent of bulbar duodenitis in duodenal ulcer, endoscopic and histological study. Endoscopy 14:193–195, 1982
Paoluzi P: Letter to the Editor. Ital J Gastroenterol 2:121, 1978
Paoluzi P, Ricotta G, Ripoli F, Proietti F, Carratù R, Torsoli A: Incompletely and completely healed duodenal ulcers' outcome in maintenance treatment: A double blind controlled study. Gut 24:A469, 1983
Whitehead R, Roca M, Meikle DD, Skinner J, Truelove SC: The histological classification of duodenitis in fiberoptic biopsy specimens. Digestion 13:129–136, 1975
Paoluzi P, Pallone F, Palazzesi P, Iannoni C, Marcheggiano A: Frequency of duodenitis in active and healed duodenal ulcer and in nonulcer dyspepsia. Ital J Gastroenterol 12:285–287, 1980
Author information
Authors and Affiliations
Additional information
Work supported in part by grant CNR, Italy 75.00879.04/115.8474 to F.P.
Rights and permissions
About this article
Cite this article
Paoluzi, P., Pallone, F., Zaccardelli, E. et al. Outcome of ulcer-associated duodenitis after short-term medical treatment. Digest Dis Sci 30, 624–629 (1985). https://doi.org/10.1007/BF01308410
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01308410