Abstract
Short-chain fatty acids (SCFAs) alter ileal and colonic motility, but their effects on duodenojejunal motility are unknown. Simultaneous jejunal manometric recordings and hydrogen breath tests after lactulose were performed in eight healthy subjects during continuous duodenal infusion of either saline or SCFAs. These experiments were conducted in the fasting state and postprandially. The effects of various boluses of SCFAs on duodenojejunal motility were also determined in six subjects. During the fasting period, the number and characteristics of migrating motor complex, prolonged propagated contractions, discrete clustered contractions, motility indes, and orocecal transit time were similar during saline and SCFAs. Similarly, the motility index and the duration of the postprandial period were not different between SCFAs and saline after the meal. The motility index was significantly increased after each of the 100-ml boluses (saline or SCFAs), but was not altered after the 12.5-ml boluses, suggesting a volume-related effect. Thus, SCFAs do not seem to affect proximal small bowel motility in healthy humans.
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References
Cummings JH: Short chain fatty acids in the human colon. Gut 22:763–779, 1981
Cummings JH, Englyst HN: Fermentation in the human large intestine and the available substrates. Am J Clin Nutr 45:1243–1255, 1987
Kamath PS, Hoepfner MT, Phillips SF: Short-chain fatty acids stimulate motility of canine ileum. Am J Physiol 253:G427-G433, 1987
Kamath PS, Phillips SF: Initiation of motility in canine ileum by short-chain fatty acids and inhibition by pharmacological agents. Gut 29:941–948, 1988
Kamath PS, Phillips SF, Zinsmeister AR: Short-chain fatty acids stimulate ileal motility in humans. Gastroenterology 95:1496–1502, 1988
Sarna S: Giant migrating contractions and their myoelectric correlates in the small intestine. Am J Physiol 253(Gastrointest. Liver Physiol 16): G697-G705, 1987
Hoverstad T, Bjorneklett A, Fausa O, Midvedt T: Shortchain fatty acids in the small-bowel bacterial overgrowth syndrome. Scand J Gastroenterol 20:492–499, 1985
Hoverstad T, Bjorneklett A, Midvedt T, Fausa O, Bohmer T: Short-chain fatty acids in the proximal gastrointestinal tract of healthy subjects. Scand J Gastroenterol 19:1053–1058, 1984
Bond JH, Levitt MD: Investigation of the small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med 85:546–555, 1975
Yajima T: Contractile effect of short-chain fatty acids on the isolated colon of the rat. J Physiol 368:667–678, 1985
Vantrappen G, Janssens J, Hellemans J, Ghoos Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158–1166, 1977
Cummings JH, Pomare EW, Branch WJ, Naylor CDE, Macfarlane GT: Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28:1221–1227, 1987
Illman RJ, Topping DL, McIntosh GH, Trimble RP, Stover GB, Taylor MN, Cheng BQ: Hypocholesterolaemic effects of dietary propionate: Studies in whole animals and perfused rat liver. Ann Nutr Metab 32:97–107, 1988
Fich A, Phillips SF, Hakim N, Brown ML, Zinsmeister AR: Stimulation of ileal emptying by short chain fatty acids. Dig Dis Sci 34:1516–1520, 1989
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This work was supported in part by a research grant from Institut National de la Santé et de la Recherche Médicale (INSERM) (CRE 887009), and by Smith Kline and French (Paris, France).
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Masliah, C., Cherbut, C., Bruley des Varannes, S. et al. Short-chain fatty acids do not alter jejunal motility in man. Digest Dis Sci 37, 193–197 (1992). https://doi.org/10.1007/BF01308171
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DOI: https://doi.org/10.1007/BF01308171