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Gardner's syndrome

Recent developments in research and management

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Abstract

In recent years, a number of comprehensive reviews have been written on inherited intestinal polyposis syndromes (1–7), but none has dealt specifically with Gardner's syndrome and none has focused on basic research being carried out in an attempt to under-stand this syndrome and to improve the medical management of affected patients. A better understanding of this rare genetic disorder is essential for surgeons, gastroenterologists, cancer researchers, and geneticists alike. To the clinician, it poses difficult challenges in management; to the cancer researcher, it presents a rare opportunity to study very early premalignant transformations; and to the geneticist, it poses exciting questions at the cellular, chromosomal, and molecular levels.

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  1. State University of New York at Buffalo, 3435 Main Street, 14214, Buffalo, New York

    Edwin W. Naylor PhD & Emanuel Lebenthal MD

  2. Divisions of Human Genetics and Gastroenterology, The Children's Hospital of Buffalo, 14214, Buffalo, New York

    Edwin W. Naylor PhD & Emanuel Lebenthal MD

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Supported in part by Maternal and Child Health Service Project No. 417.

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Naylor, E.W., Lebenthal, E. Gardner's syndrome. Digest Dis Sci 25, 945–959 (1980). https://doi.org/10.1007/BF01308046

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