Abstract
This study tested the hypothesis that (alginic) acid may have a preferential effect on reflux in the upright position. We evaluated the effect of a compound containing alginic acid plus antacid (extrastrength Gaviscon) versus active control antacid with equal acidneutralizing capacity on intraesophageal acid exposure following a high-fat, meal (61% fat: sausage, egg, and biscuit). In random sequence, each of the 10 volunteers received either alginic acid-antacid or control antacid immediately following and 1, 2, and 3 hr after the meal. The sequence was repeated for both test drugs in the supine and upright positions with constant pH monitoring. Alginic acid-antacid significantly decreased postprandial reflux in the upright position compared to an equal amount of antacid. This effect did not occur in the supine position. These findings support the hypothesis that alginic acid is primarily effective in the upright position and the clinical observations of the effectiveness of alginic acid on daytime reflux symptoms.
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References
Beckloff GL, Chapman JH, Shiverdecker P: Objective evaluation of an antacid with unusual properties. J Clin Pharm 12:11–21, 1972
Becker D, Sinclair J, Castell D, Wu W: A comparison of high and low fat meals on postprandial esophageal acid exposure. Am J Gastroenterol 84:782–786, 1989
Clark CS, Kraus BB, Sinclair J, Castell DO: Gastroesophageal reflux induced by exercise in healthy volunteers. JAMA 261:3599–3601, 1989
Langley R: Practical Statistics Simply Explained, revised edition. New York, Dover, 1971, pp. 254–268
Johnson NJ, Boyd EJ, Mills JG, Wood, JR: Acute treatment of reflux oesophagitis. Aliment Pharmacol Ther 3:259–266, 1989
Collen M, Lewis J, Benjamin S: Gastric acid hypersecretion in refractory gastroesophageal reflux disease. Gastroenterology 98:600–605, 1990
Moss HA, Washington N, Greaves JL, Wilson C: Antireflux agents. Stratification of or flotation? Eur J Gastroenterol Hepatol 2:45–51, 1990
Stanciu C, Bennett JR: Alginate/antacid in the reduction of gastroesophageal reflux. Lancet 1:109–111, 1974
McHardy G: A multicentric randomized clinical trial of Gaviscon in reflux esophagitis. South Med J 71(Suppl):16–21, 1978
Lanza F, Smith V, Page-Castell J, Castell D: Effectiveness of foaming antacid in relieving induced heartburn. South Med J 79:327–330, 1986
Johnson LF, DeMeester TR: Evaluation of elevation of the head of the bed, bethanechol, and antacid foam tablets on gastroesophageal reflux. Dig Dis Sci 26:673–680, 1981
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Castell, D.O., Dalton, C.B., Becker, D. et al. Alginic acid decreases postprandial upright gastroesophageal reflux. Digest Dis Sci 37, 589–593 (1992). https://doi.org/10.1007/BF01307584
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DOI: https://doi.org/10.1007/BF01307584