Abstract
Intracellular microelectrodes were used to study the effects of prolonged exposure to histamine on the electrophysiological behavior of AH/type-2 neurons in the myenteric plexus of the guinea pig small intestine. Application of histamine activated H2 receptors to convert the neurons to a heightened state of excitability. Heightened excitability was evident as repetitive spike discharge made possible, in part, by suppression of postspike after-hyperpolarization. The hyperexcitable state persisted unchanged for prolonged periods, of 4.5 hr in the continued presence of histamine, suggesting that desensitization may never occurin vivo. The results are interpreted as a neural correlate for the pathophysiology associated with microscopic colitis and other inflammatory conditions involving mast cell hyperplasia.
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Wood JD: Communication between minibrain in gut and enteric immune system. NIPS 6:64–69, 1991
Wang YZ, Palmer JM, Cooke HJ: Neuro-immune regulation of colonic secretion in guinea pigs. Am J Physiol 260:G307-G314, 1991
Wang YZ, Cooke HJ: H2 receptors mediate cyclical chloride secretion in guinea pig distal colon. Am J Physiol 258:G887-G893, 1990
Cooke HJ, Frieling T, Wang Y-Z, Wood JD: Neuroimmuno-modulation of intestinal chloride secretion.In Exocrine Secretion II. PYD Wong, JA Young (eds). Hong Kong, United League Graphic and Printing, 1990, pp 39–42
Baum CA, Paramjit B, Miner PB: Increased colonic mucosal mast cells associated with severe watery diarrhea and microscopic colitis. Dig Dis Sci 34:1462–1465, 1989
Nemeth PR, Ort CA, Wood JD: Intracellular study of effects of histamine on electrical behavior of myenteric neurons in guinea-pig small intestine. J Physiol (London) 355:411–425, 1984
Frieling T, Cooke HJ, Wood JD: Intracellular study of actions of the inflammatory mediator histamine on electrical and synaptic behavior of submucosal neurons in guinea-pig colon. Gastroenterology 96:A160, 1989
Wood JD: Electrical and synaptic behavior of enteric neurons.In Handbook of Physiology—The Gastrointestinal System, Motility and Circulation, Vol 1, Sect 6. JD Wood (ed). Oxford, Oxford University Press, 1989, pp 465–517
Wood JD: Physiology of the enteric nervous systemIn Physiology of the Gastrointestinal Tract, 2nd ed. LR Johnson (ed). New York, Raven Press, 1987, pp 67–109
Tamura K, Wood JD: Electrical and synaptic properties of myenteric plexus neurones in the terminal large intestine of the guinea-pig. J Physiol (London) 415:275–298, 1989
Tamura K, Palmer JM, Wood JD: Presynaptic inhibition produced by histamine at nicotine synapses in enteric ganglia. Neurosciences 25:171–179, 1987
Wood JD, Mayer CJ: Intracellular study of electrical activity of Auerbach's plexus in guinea-pig small intestine. Pfluegers Arch 374:265–275, 1978
Cooke HJ, Nemeth PR, Wood JD: Histamine action on guinea-pig ileal mucosa. Am J Physiol 246:G372-G377, 1984
Nolte H, Spjeldnaes N, Kruse A, Windelborg B: Histamine release from gut mast cells from patients with inflammatory bowel diseases. Gut 31:791–794, 1990
Molas GJ, Flejou JF, Potet F: Microscopic colitis, collagenous colitis, and mast cells. Dig Dis Sci 35:920–921, 1990
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Tamura, K., Wood, J.D. Effects of prolonged exposure to histamine on guinea pig intestinal neurons. Digest Dis Sci 37, 1084–1088 (1992). https://doi.org/10.1007/BF01300291
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DOI: https://doi.org/10.1007/BF01300291