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A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents

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Abstract

Newer nonsteroidal antiinflammatory, agents (NSAIs) such as ibuprofen, naproxen, fenoprofen, and tolmetin have broadened the therapeutic choice and increased the chances of providing optimum arthritis control, but require careful assessment of the possibilities for unwanted drug effects when long-term therapy is required. A review of the literature on the gastrointestinal effects of the promising newer NSAIs, as compared with the older agents, aspirin, indomethacin, and phenylbutazone, is presented, highlighting animal toxicology and human adverse reaction surveillance data and the evidence for various suggested pathophysiological mechanisms.

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  1. Syntex Laboratories, 3401 Hilview Avenue, 94304, Palo Alto, California

    Russell E. Pemberton MD, PhD &  L. James Strand MD (an assistant, professor of clinical medicine at Stanford Medical School at Palo Alto)

  2. University of California Medical Center, San Francisco, California

    Russell E. Pemberton MD, PhD

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Pemberton, R.E., Strand, L.J. A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents. Digest Dis Sci 24, 53–64 (1979). https://doi.org/10.1007/BF01297239

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